Evolutionary analysis and functional characterization of the forkhead transcription factor FoxG1

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dc.contributor.advisor Illing, Nicola en_ZA
dc.contributor.author Bredenkamp, Nicholas en_ZA
dc.date.accessioned 2014-07-30T17:35:36Z
dc.date.available 2014-07-30T17:35:36Z
dc.date.issued 2006 en_ZA
dc.identifier.uri http://hdl.handle.net/11427/4243
dc.description Includes bibliographical references (leaves 103-110).
dc.description.abstract Forhead box G1 (FoxG1) is a winged-helix transcription factor that plays a crucial role in the development of the telecephalon, the most rostral region of the brain Here, FoxG1 acts as a transcriptional repressor and maintains the population of cortical progenitor cells by promoting their proliferation and inhibiting differrentiation. Vertebrate FoxG1 orthologs have highly conserved DNA-binding and corbosy-terminal domains that have functional roles. Conversely, no functional role has yet been assigned to the N-terminal domain which shows a high degree of variability across vertebrates, with a remarkable stretch of consecutive histidine, proline and glutamine (HPQ) residues in the mammalian orthologs. In this study it was tested whether differences in FoxG1 sequence amongst vertebrates might account for the increased cortex size of mammals compared to non-mammals. Furthermore, changes in the sub-cellular localization of FoxG1 in response to fibroblast growth factor 2 (FGF-2) were investigated in a neural precursor cell line. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Molecular Biology en_ZA
dc.title Evolutionary analysis and functional characterization of the forkhead transcription factor FoxG1 en_ZA
dc.type Thesis en_ZA
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Science en_ZA
dc.publisher.department Department of Molecular and Cell Biology en_ZA
dc.type.qualificationlevel Masters en_ZA
dc.type.qualificationname MSc en_ZA
uct.type.filetype Text
uct.type.filetype Image

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