dc.contributor.advisor |
Combrinck, Marc |
en_ZA |
dc.contributor.author |
Allie, Sameera
|
en_ZA |
dc.date.accessioned |
2014-07-29T09:38:54Z |
|
dc.date.available |
2014-07-29T09:38:54Z |
|
dc.date.issued |
2013 |
en_ZA |
dc.identifier.citation |
Allie, S. 2013. The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke. University of Cape Town. |
en_ZA |
dc.identifier.uri |
http://hdl.handle.net/11427/3501
|
|
dc.description |
Includes abstract. |
|
dc.description |
Includes bibliographical references. |
|
dc.description.abstract |
The Human Immunodeficiency Virus (HIV) is neuro-invasive and neurological complications of HIV infection occur frequently through a variety of possible mechanisms. Stroke in the setting of HIV is not uncommonly seen in young adults. High levels of von Willebrand factor (VWF), a protein with key roles in platelet adhesion and aggregation, and low levels of A Disintegrin and Metalloproteinase with a Thrombospondin type 1 motif, member 13 (ADAMTS13), the protease that cleaves ultra large VWF multimers into smaller less haemostatically active multimers, have been associated with an increased propensity for thrombosis. Stroke is a potential complication of the aberrant activity of these two proteins. HIV infection has also been associated with endothelial dysfunction, and VWF is a marker of the latter. The investigation of VWF and ADAMTS13 may therefore provide new insights into the pathogenesis of HIV-related stroke. |
en_ZA |
dc.language.iso |
eng |
en_ZA |
dc.subject.other |
Medicine |
en_ZA |
dc.title |
The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke. |
en_ZA |
dc.type |
Master Thesis |
|
uct.type.publication |
Research |
en_ZA |
uct.type.resource |
Thesis
|
en_ZA |
dc.publisher.institution |
University of Cape Town |
|
dc.publisher.faculty |
Faculty of Health Sciences |
en_ZA |
dc.publisher.department |
Department of Medicine |
en_ZA |
dc.type.qualificationlevel |
Masters |
|
dc.type.qualificationname |
MSc |
en_ZA |
uct.type.filetype |
Text |
|
dc.identifier.apacitation |
Allie, S. (2013). <i>The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/3501 |
en_ZA |
dc.identifier.chicagocitation |
Allie, Sameera. <i>"The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2013. http://hdl.handle.net/11427/3501 |
en_ZA |
dc.identifier.vancouvercitation |
Allie S. The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3501 |
en_ZA |
dc.identifier.ris |
TY - Thesis / Dissertation
AU - Allie, Sameera
AB - The Human Immunodeficiency Virus (HIV) is neuro-invasive and neurological complications of HIV infection occur frequently through a variety of possible mechanisms. Stroke in the setting of HIV is not uncommonly seen in young adults. High levels of von Willebrand factor (VWF), a protein with key roles in platelet adhesion and aggregation, and low levels of A Disintegrin and Metalloproteinase with a Thrombospondin type 1 motif, member 13 (ADAMTS13), the protease that cleaves ultra large VWF multimers into smaller less haemostatically active multimers, have been associated with an increased propensity for thrombosis. Stroke is a potential complication of the aberrant activity of these two proteins. HIV infection has also been associated with endothelial dysfunction, and VWF is a marker of the latter. The investigation of VWF and ADAMTS13 may therefore provide new insights into the pathogenesis of HIV-related stroke.
DA - 2013
DB - OpenUCT
DP - University of Cape Town
LK - https://open.uct.ac.za
PB - University of Cape Town
PY - 2013
T1 - The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke
TI - The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke
UR - http://hdl.handle.net/11427/3501
ER -
|
en_ZA |