The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke.

 

Show simple item record

dc.contributor.advisor Combrinck, Marc en_ZA
dc.contributor.author Allie, Sameera en_ZA
dc.date.accessioned 2014-07-29T09:38:54Z
dc.date.available 2014-07-29T09:38:54Z
dc.date.issued 2013 en_ZA
dc.identifier.citation Allie, S. 2013. The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/3501
dc.description Includes abstract.
dc.description Includes bibliographical references.
dc.description.abstract The Human Immunodeficiency Virus (HIV) is neuro-invasive and neurological complications of HIV infection occur frequently through a variety of possible mechanisms. Stroke in the setting of HIV is not uncommonly seen in young adults. High levels of von Willebrand factor (VWF), a protein with key roles in platelet adhesion and aggregation, and low levels of A Disintegrin and Metalloproteinase with a Thrombospondin type 1 motif, member 13 (ADAMTS13), the protease that cleaves ultra large VWF multimers into smaller less haemostatically active multimers, have been associated with an increased propensity for thrombosis. Stroke is a potential complication of the aberrant activity of these two proteins. HIV infection has also been associated with endothelial dysfunction, and VWF is a marker of the latter. The investigation of VWF and ADAMTS13 may therefore provide new insights into the pathogenesis of HIV-related stroke. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Medicine en_ZA
dc.title The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke. en_ZA
dc.type Thesis / Dissertation en_ZA
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Medicine en_ZA
dc.type.qualificationlevel Masters en_ZA
dc.type.qualificationname MSc en_ZA
uct.type.filetype Text


Files in this item

This item appears in the following Collection(s)

Show simple item record