The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke.

 

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dc.contributor.advisor Combrinck, Marc en_ZA
dc.contributor.author Allie, Sameera en_ZA
dc.date.accessioned 2014-07-29T09:38:54Z
dc.date.available 2014-07-29T09:38:54Z
dc.date.issued 2013 en_ZA
dc.identifier.citation Allie, S. 2013. The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/3501
dc.description Includes abstract.
dc.description Includes bibliographical references.
dc.description.abstract The Human Immunodeficiency Virus (HIV) is neuro-invasive and neurological complications of HIV infection occur frequently through a variety of possible mechanisms. Stroke in the setting of HIV is not uncommonly seen in young adults. High levels of von Willebrand factor (VWF), a protein with key roles in platelet adhesion and aggregation, and low levels of A Disintegrin and Metalloproteinase with a Thrombospondin type 1 motif, member 13 (ADAMTS13), the protease that cleaves ultra large VWF multimers into smaller less haemostatically active multimers, have been associated with an increased propensity for thrombosis. Stroke is a potential complication of the aberrant activity of these two proteins. HIV infection has also been associated with endothelial dysfunction, and VWF is a marker of the latter. The investigation of VWF and ADAMTS13 may therefore provide new insights into the pathogenesis of HIV-related stroke. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Medicine en_ZA
dc.title The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke. en_ZA
dc.type Master Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Medicine en_ZA
dc.type.qualificationlevel Masters
dc.type.qualificationname MSc en_ZA
uct.type.filetype Text
dc.identifier.apacitation Allie, S. (2013). <i>The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/3501 en_ZA
dc.identifier.chicagocitation Allie, Sameera. <i>"The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2013. http://hdl.handle.net/11427/3501 en_ZA
dc.identifier.vancouvercitation Allie S. The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3501 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Allie, Sameera AB - The Human Immunodeficiency Virus (HIV) is neuro-invasive and neurological complications of HIV infection occur frequently through a variety of possible mechanisms. Stroke in the setting of HIV is not uncommonly seen in young adults. High levels of von Willebrand factor (VWF), a protein with key roles in platelet adhesion and aggregation, and low levels of A Disintegrin and Metalloproteinase with a Thrombospondin type 1 motif, member 13 (ADAMTS13), the protease that cleaves ultra large VWF multimers into smaller less haemostatically active multimers, have been associated with an increased propensity for thrombosis. Stroke is a potential complication of the aberrant activity of these two proteins. HIV infection has also been associated with endothelial dysfunction, and VWF is a marker of the latter. The investigation of VWF and ADAMTS13 may therefore provide new insights into the pathogenesis of HIV-related stroke. DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke TI - The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke UR - http://hdl.handle.net/11427/3501 ER - en_ZA


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