Expression, purification and characterisation of protoporphyrinogen oxidases from diverse species

 

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dc.contributor.advisor Meissner, Peter en_ZA
dc.contributor.advisor Corrigall, Anne en_ZA
dc.contributor.author Siziba, Kwanele Bennett en_ZA
dc.date.accessioned 2014-07-29T09:10:30Z
dc.date.available 2014-07-29T09:10:30Z
dc.date.issued 2000 en_ZA
dc.identifier.citation Siziba, K. 2000. Expression, purification and characterisation of protoporphyrinogen oxidases from diverse species. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/3464
dc.description Bibliography: leaves 163-203.
dc.description.abstract This work involved the characterisation of protoporphyrinogen oxidase (PPO), the penultimate enzyme in haem biosynthesis, from Bacillus subtilis, Myxococcus xanthus, and human. A defect in human PPO causes variegate porphyria, an autosomal dominant disorder characterised by skin photosensitivity and propensity towards acute neurovisceral crises. At the beginning of this project little information was available on the kinetic and biophysical properties of isolated PPOs due largely to difficulties associated with their purification from natural sources. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Medicine en_ZA
dc.title Expression, purification and characterisation of protoporphyrinogen oxidases from diverse species en_ZA
dc.type Doctoral Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Medicine en_ZA
dc.type.qualificationlevel Doctoral
dc.type.qualificationname PhD en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Siziba, K. B. (2000). <i>Expression, purification and characterisation of protoporphyrinogen oxidases from diverse species</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/3464 en_ZA
dc.identifier.chicagocitation Siziba, Kwanele Bennett. <i>"Expression, purification and characterisation of protoporphyrinogen oxidases from diverse species."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2000. http://hdl.handle.net/11427/3464 en_ZA
dc.identifier.vancouvercitation Siziba KB. Expression, purification and characterisation of protoporphyrinogen oxidases from diverse species. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2000 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3464 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Siziba, Kwanele Bennett AB - This work involved the characterisation of protoporphyrinogen oxidase (PPO), the penultimate enzyme in haem biosynthesis, from Bacillus subtilis, Myxococcus xanthus, and human. A defect in human PPO causes variegate porphyria, an autosomal dominant disorder characterised by skin photosensitivity and propensity towards acute neurovisceral crises. At the beginning of this project little information was available on the kinetic and biophysical properties of isolated PPOs due largely to difficulties associated with their purification from natural sources. DA - 2000 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2000 T1 - Expression, purification and characterisation of protoporphyrinogen oxidases from diverse species TI - Expression, purification and characterisation of protoporphyrinogen oxidases from diverse species UR - http://hdl.handle.net/11427/3464 ER - en_ZA


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