The susceptibility of baboons to the novel immunosuppressant, FTY720

 

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dc.contributor.advisor Quesniaux, Valerie en_ZA
dc.contributor.author Semple, P L en_ZA
dc.date.accessioned 2014-07-29T09:10:28Z
dc.date.available 2014-07-29T09:10:28Z
dc.date.issued 2000 en_ZA
dc.identifier.citation Semple, P. 2000. The susceptibility of baboons to the novel immunosuppressant, FTY720. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/3463
dc.description Bibliography: leaves 109-118.
dc.description.abstract Since there is a major scarcity of donor organs world-wide, the experimental search for human organs has focused on two alternatives; mechanical devices and cross-species transplants. The use of mechanical devices as substitute organs is understandably limited due to complications from trying to duplicate the function of complex organs such as the liver. This has resulted in a renewed interest in xenotransplantation. Organs from non-human primates would arguably be the organs of choice but ethical consideration prevents this. The transplantation of organs from pigs or sheep to humans i.e. xenotransplants, results in hyperacute rejection. The development of immunosuppressive agents such as Cyc1osporine A and Tacrolimus have significantly improved the survival of organ transplants. However, although there is a good 1-5 year survival, the recurrent problem of chronic rejection still remains, and unresponsiveness to allografts has never been induced by these immunosuppressive agents. More importantly, the presence of adverse side effects including immunological complications and drug toxicity e.g. nephrotoxicity, remains a serious problem. Since the drugs currently available for allotransplantation preferably target T -cells, and are therefore unlikely to be sufficient for xenotransplantation where there is a strong B-cell driven response, there is a need for new immunosuppressive agents. FTY720 (2 amino-2-(2-[ 4-octylphenyl] ethyl)-1,3-propanediol hydrochloride), a novel, immunosuppressive drug active in rodent and dog transplantation models, has shown no toxic side effects in pre-clinical studies although no long-term patient studies exist. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Medicine en_ZA
dc.title The susceptibility of baboons to the novel immunosuppressant, FTY720 en_ZA
dc.type Master Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Medicine en_ZA
dc.type.qualificationlevel Masters
dc.type.qualificationname MSc en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Semple, P. L. (2000). <i>The susceptibility of baboons to the novel immunosuppressant, FTY720</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/3463 en_ZA
dc.identifier.chicagocitation Semple, P L. <i>"The susceptibility of baboons to the novel immunosuppressant, FTY720."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2000. http://hdl.handle.net/11427/3463 en_ZA
dc.identifier.vancouvercitation Semple PL. The susceptibility of baboons to the novel immunosuppressant, FTY720. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2000 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3463 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Semple, P L AB - Since there is a major scarcity of donor organs world-wide, the experimental search for human organs has focused on two alternatives; mechanical devices and cross-species transplants. The use of mechanical devices as substitute organs is understandably limited due to complications from trying to duplicate the function of complex organs such as the liver. This has resulted in a renewed interest in xenotransplantation. Organs from non-human primates would arguably be the organs of choice but ethical consideration prevents this. The transplantation of organs from pigs or sheep to humans i.e. xenotransplants, results in hyperacute rejection. The development of immunosuppressive agents such as Cyc1osporine A and Tacrolimus have significantly improved the survival of organ transplants. However, although there is a good 1-5 year survival, the recurrent problem of chronic rejection still remains, and unresponsiveness to allografts has never been induced by these immunosuppressive agents. More importantly, the presence of adverse side effects including immunological complications and drug toxicity e.g. nephrotoxicity, remains a serious problem. Since the drugs currently available for allotransplantation preferably target T -cells, and are therefore unlikely to be sufficient for xenotransplantation where there is a strong B-cell driven response, there is a need for new immunosuppressive agents. FTY720 (2 amino-2-(2-[ 4-octylphenyl] ethyl)-1,3-propanediol hydrochloride), a novel, immunosuppressive drug active in rodent and dog transplantation models, has shown no toxic side effects in pre-clinical studies although no long-term patient studies exist. DA - 2000 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2000 T1 - The susceptibility of baboons to the novel immunosuppressant, FTY720 TI - The susceptibility of baboons to the novel immunosuppressant, FTY720 UR - http://hdl.handle.net/11427/3463 ER - en_ZA


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