Optimization of structural and mechanical properties of electro-spun biodegradable scaffolds for vascular vissue regeneration

 

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dc.contributor.advisor Franz, Thomas en_ZA
dc.contributor.advisor Krynauw, Hugo en_ZA
dc.contributor.advisor Bezuidenhout, Deon en_ZA
dc.contributor.author Khatib, Rodaina Omar en_ZA
dc.date.accessioned 2014-07-29T09:04:08Z
dc.date.available 2014-07-29T09:04:08Z
dc.date.issued 2013 en_ZA
dc.identifier.citation Khatib, R. 2013. Optimization of structural and mechanical properties of electro-spun biodegradable scaffolds for vascular vissue regeneration. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/3408
dc.description Includes abstract.
dc.description Includes bibliographical references.
dc.description.abstract Current replacements for diseased arteries include autologous and artificial grafts. The availability of autologous grafts is limited and artificial grafts tend to fail when applied to small calibre vessels (<;6 mm) due to graft thrombosis and mechanical mismatch between artery and graft. Tissue engineering offers a promising approach to overcome these shortcomings. With porosity as a fundamental prerequisite for tissue ingrowth, several techniques have been introduced for producing porous scaffolds including electro-spinning. This study involved the development and optimisation of electro-spun biodegradable scaffolds for vascular tissue regeneration by tailoring parameters of the electro-spinning process and investigating the change in mechanical and physical properties of the scaffolds associated with hydrolytic in vitro degradation. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Medicine en_ZA
dc.title Optimization of structural and mechanical properties of electro-spun biodegradable scaffolds for vascular vissue regeneration en_ZA
dc.type Master Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Medicine en_ZA
dc.type.qualificationlevel Masters
dc.type.qualificationname MSc en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Khatib, R. O. (2013). <i>Optimization of structural and mechanical properties of electro-spun biodegradable scaffolds for vascular vissue regeneration</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/3408 en_ZA
dc.identifier.chicagocitation Khatib, Rodaina Omar. <i>"Optimization of structural and mechanical properties of electro-spun biodegradable scaffolds for vascular vissue regeneration."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2013. http://hdl.handle.net/11427/3408 en_ZA
dc.identifier.vancouvercitation Khatib RO. Optimization of structural and mechanical properties of electro-spun biodegradable scaffolds for vascular vissue regeneration. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3408 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Khatib, Rodaina Omar AB - Current replacements for diseased arteries include autologous and artificial grafts. The availability of autologous grafts is limited and artificial grafts tend to fail when applied to small calibre vessels (<;6 mm) due to graft thrombosis and mechanical mismatch between artery and graft. Tissue engineering offers a promising approach to overcome these shortcomings. With porosity as a fundamental prerequisite for tissue ingrowth, several techniques have been introduced for producing porous scaffolds including electro-spinning. This study involved the development and optimisation of electro-spun biodegradable scaffolds for vascular tissue regeneration by tailoring parameters of the electro-spinning process and investigating the change in mechanical and physical properties of the scaffolds associated with hydrolytic in vitro degradation. DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Optimization of structural and mechanical properties of electro-spun biodegradable scaffolds for vascular vissue regeneration TI - Optimization of structural and mechanical properties of electro-spun biodegradable scaffolds for vascular vissue regeneration UR - http://hdl.handle.net/11427/3408 ER - en_ZA


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