Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation

 

Show simple item record

dc.contributor.advisor Heckmann, Jeannine en_ZA
dc.contributor.advisor Dandara, Collet en_ZA
dc.contributor.author Centner, Chad en_ZA
dc.date.accessioned 2014-07-29T09:02:54Z
dc.date.available 2014-07-29T09:02:54Z
dc.date.issued 2012 en_ZA
dc.identifier.citation Centner, C. 2012. Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/3370
dc.description.abstract Both human immunodeficiency virus (HIV) infection and tuberculosis (TB) are complicated by a painful distal sensory polyneuropathy (DSP) that may be due to virus-related HIV-DSP, antiretroviral toxic neuropathy (ATN) or isoniazid-induced peripheral neuropathy (INH-PN). In co-infection with and co-treatment for HIV/TB, DSP risk is increased. Factors driving this risk may be vitamin B6 deficiency and slow metabolism of INH mediated by N-acetyltransferase 2 (NAT2) acetylation, both known risk en_ZA
dc.language.iso eng en_ZA
dc.subject.other Medicine en_ZA
dc.title Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation en_ZA
dc.type Master Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Medicine en_ZA
dc.type.qualificationlevel Masters
dc.type.qualificationname MMed en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Centner, C. (2012). <i>Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/3370 en_ZA
dc.identifier.chicagocitation Centner, Chad. <i>"Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2012. http://hdl.handle.net/11427/3370 en_ZA
dc.identifier.vancouvercitation Centner C. Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2012 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3370 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Centner, Chad AB - Both human immunodeficiency virus (HIV) infection and tuberculosis (TB) are complicated by a painful distal sensory polyneuropathy (DSP) that may be due to virus-related HIV-DSP, antiretroviral toxic neuropathy (ATN) or isoniazid-induced peripheral neuropathy (INH-PN). In co-infection with and co-treatment for HIV/TB, DSP risk is increased. Factors driving this risk may be vitamin B6 deficiency and slow metabolism of INH mediated by N-acetyltransferase 2 (NAT2) acetylation, both known risk DA - 2012 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation TI - Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation UR - http://hdl.handle.net/11427/3370 ER - en_ZA


Files in this item

This item appears in the following Collection(s)

Show simple item record