Addressing Latent Tuberculosis: New Advances in Mimicking the Disease, Discovering Key Targets, and Designing Hit Compounds

 

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dc.contributor.author Campaniço, André
dc.contributor.author Harjivan, Shrika G.
dc.contributor.author Warner, Digby F.
dc.contributor.author Moreira, Rui
dc.contributor.author Lopes, Francisca
dc.date.accessioned 2021-06-29T17:09:02Z
dc.date.available 2021-06-29T17:09:02Z
dc.date.issued 2020-11-23
dc.identifier doi: 10.3390/ijms21228854
dc.identifier.uri http://hdl.handle.net/11427/33418
dc.description.abstract Despite being discovered and isolated more than one hundred years ago, tuberculosis (TB) remains a global public health concern arch. Our inability to eradicate this bacillus is strongly related with the growing resistance, low compliance to current drugs, and the capacity of the bacteria to coexist in a state of asymptomatic latency. This last state can be sustained for years or even decades, waiting for a breach in the immune system to become active again. Furthermore, most current therapies are not efficacious against this state, failing to completely clear the infection. Over the years, a series of experimental methods have been developed to mimic the latent state, currently used in drug discovery, both in vitro and in vivo. Most of these methods focus in one specific latency inducing factor, with only a few taking into consideration the complexity of the granuloma and the genomic and proteomic consequences of each physiological factor. A series of targets specifically involved in latency have been studied over the years with promising scaffolds being discovered and explored. Taking in account that solving the latency problem is one of the keys to eradicate the disease, herein we compile current therapies and diagnosis techniques, methods to mimic latency and new targets and compounds in the pipeline of drug discovery.
dc.source International Journal of Molecular Sciences
dc.source.uri https://www.mdpi.com/journal/ijms
dc.title Addressing Latent Tuberculosis: New Advances in Mimicking the Disease, Discovering Key Targets, and Designing Hit Compounds
dc.date.updated 2020-11-26T14:08:37Z
dc.source.journalvolume 21
dc.source.journalissue 22
dc.source.pagination 8854
dc.identifier.ris TY - AU - Campaniço, André AU - Harjivan, Shrika G. AU - Warner, Digby F. AU - Moreira, Rui AU - Lopes, Francisca AB - Despite being discovered and isolated more than one hundred years ago, tuberculosis (TB) remains a global public health concern arch. Our inability to eradicate this bacillus is strongly related with the growing resistance, low compliance to current drugs, and the capacity of the bacteria to coexist in a state of asymptomatic latency. This last state can be sustained for years or even decades, waiting for a breach in the immune system to become active again. Furthermore, most current therapies are not efficacious against this state, failing to completely clear the infection. Over the years, a series of experimental methods have been developed to mimic the latent state, currently used in drug discovery, both in vitro and in vivo. Most of these methods focus in one specific latency inducing factor, with only a few taking into consideration the complexity of the granuloma and the genomic and proteomic consequences of each physiological factor. A series of targets specifically involved in latency have been studied over the years with promising scaffolds being discovered and explored. Taking in account that solving the latency problem is one of the keys to eradicate the disease, herein we compile current therapies and diagnosis techniques, methods to mimic latency and new targets and compounds in the pipeline of drug discovery. DA - 2020-11-23 DB - OpenUCT DP - University of Cape Town IS - 22 J1 - International Journal of Molecular Sciences LK - https://open.uct.ac.za PY - 2020 T1 - Addressing Latent Tuberculosis: New Advances in Mimicking the Disease, Discovering Key Targets, and Designing Hit Compounds TI - Addressing Latent Tuberculosis: New Advances in Mimicking the Disease, Discovering Key Targets, and Designing Hit Compounds UR - http://hdl.handle.net/11427/33418 ER - en_ZA


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