Isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children

 

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dc.contributor.advisor McIlleron, Helen en_ZA
dc.contributor.advisor Smith, Pete en_ZA
dc.contributor.author Amlabu, Veronica Asibi en_ZA
dc.date.accessioned 2014-07-28T18:21:09Z
dc.date.available 2014-07-28T18:21:09Z
dc.date.issued 2013 en_ZA
dc.identifier.citation Amlabu, V. 2013. Isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/3307
dc.description Includes abstract.
dc.description Includes bibliographical references.
dc.description.abstract The World Health Organization recommends the use of isoniazid preventive therapy to reduce the incidence of tuberculosis disease in populations at risk for developing the disease. Adherence to isoniazid preventive therapy is needful for efficacy. A urine assay known as the Arkansas test is widely used to monitor the ingestion of isoniazid. However, this test is limited by a drop in sensitivity with increasing time post isoniazid dose. Furthermore, results from the test can be affected by observer variation in colour changes, concomitant medications, urinary dilution, and presence of other substances in urine. Moreover, the Arkansas test results have not been evaluated against objective measurement of isoniazid and acetylisoniazid urine concentrations. This study seeks to measure the urine concentrations of isoniazid and acetylisoniazid at different time points after a dose in children, in order to establish reference ranges for liquid chromatography tandem mass spectrometry measurements of urine isoniazid and acetylisoniazid, as well as the Arkansas method. The reference ranges would provide a standard which can be used to estimate the probability of adherence to prior doses. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Pharmacology en_ZA
dc.title Isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children en_ZA
dc.type Master Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Clinical Pharmacology en_ZA
dc.type.qualificationlevel Masters
dc.type.qualificationname MMed en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Amlabu, V. A. (2013). <i>Isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology. Retrieved from http://hdl.handle.net/11427/3307 en_ZA
dc.identifier.chicagocitation Amlabu, Veronica Asibi. <i>"Isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 2013. http://hdl.handle.net/11427/3307 en_ZA
dc.identifier.vancouvercitation Amlabu VA. Isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3307 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Amlabu, Veronica Asibi AB - The World Health Organization recommends the use of isoniazid preventive therapy to reduce the incidence of tuberculosis disease in populations at risk for developing the disease. Adherence to isoniazid preventive therapy is needful for efficacy. A urine assay known as the Arkansas test is widely used to monitor the ingestion of isoniazid. However, this test is limited by a drop in sensitivity with increasing time post isoniazid dose. Furthermore, results from the test can be affected by observer variation in colour changes, concomitant medications, urinary dilution, and presence of other substances in urine. Moreover, the Arkansas test results have not been evaluated against objective measurement of isoniazid and acetylisoniazid urine concentrations. This study seeks to measure the urine concentrations of isoniazid and acetylisoniazid at different time points after a dose in children, in order to establish reference ranges for liquid chromatography tandem mass spectrometry measurements of urine isoniazid and acetylisoniazid, as well as the Arkansas method. The reference ranges would provide a standard which can be used to estimate the probability of adherence to prior doses. DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children TI - Isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children UR - http://hdl.handle.net/11427/3307 ER - en_ZA


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