The characterization of adaptor protein homologues in Plasmodium falciparum

 

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dc.contributor.advisor Hoppe, Heinrich C en_ZA
dc.contributor.author Meredith, Sandra Allison en_ZA
dc.date.accessioned 2014-07-28T18:19:16Z
dc.date.available 2014-07-28T18:19:16Z
dc.date.issued 2009 en_ZA
dc.identifier.citation Meredith, S. 2009. The characterization of adaptor protein homologues in Plasmodium falciparum. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/3291
dc.description Includes abstract.
dc.description Includes bibliographical references (leaves 148-171).
dc.description.abstract Plasmodium falciparum is becoming increasingly more resistant to regular antimalarial drugs, making it necessary to identify novel drug candidates and drug targets. Components of the endocytic and secretory pathway in asexual stage parasites are attractive targets because they play a fundamental role in the normal processes of parasite metabolism. Adaptor protein complexes are components of protein coats that associate with transport vesicles of the endocytic and secretory pathways in mammalian cells. Homologues of several adaptor protein subunits are encoded by the parasite genome. The presence of these genes suggests that the parasite experiences clathrin-mediated transport processes. This study reports the cloning and characterization of selected malarial homologues of these adaptor proteins, namely three medium (μ) chain adaptin homologues and two sigma (σ) chains. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Pharmacology en_ZA
dc.title The characterization of adaptor protein homologues in Plasmodium falciparum en_ZA
dc.type Doctoral Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Clinical Pharmacology en_ZA
dc.type.qualificationlevel Doctoral
dc.type.qualificationname PhD en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Meredith, S. A. (2009). <i>The characterization of adaptor protein homologues in Plasmodium falciparum</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology. Retrieved from http://hdl.handle.net/11427/3291 en_ZA
dc.identifier.chicagocitation Meredith, Sandra Allison. <i>"The characterization of adaptor protein homologues in Plasmodium falciparum."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 2009. http://hdl.handle.net/11427/3291 en_ZA
dc.identifier.vancouvercitation Meredith SA. The characterization of adaptor protein homologues in Plasmodium falciparum. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 2009 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3291 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Meredith, Sandra Allison AB - Plasmodium falciparum is becoming increasingly more resistant to regular antimalarial drugs, making it necessary to identify novel drug candidates and drug targets. Components of the endocytic and secretory pathway in asexual stage parasites are attractive targets because they play a fundamental role in the normal processes of parasite metabolism. Adaptor protein complexes are components of protein coats that associate with transport vesicles of the endocytic and secretory pathways in mammalian cells. Homologues of several adaptor protein subunits are encoded by the parasite genome. The presence of these genes suggests that the parasite experiences clathrin-mediated transport processes. This study reports the cloning and characterization of selected malarial homologues of these adaptor proteins, namely three medium (μ) chain adaptin homologues and two sigma (σ) chains. DA - 2009 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - The characterization of adaptor protein homologues in Plasmodium falciparum TI - The characterization of adaptor protein homologues in Plasmodium falciparum UR - http://hdl.handle.net/11427/3291 ER - en_ZA


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