The characterization of adaptor protein homologues in Plasmodium falciparum

Meredith, Sandra Allison

dc.contributor.advisor	Hoppe, Heinrich C	en_ZA
dc.contributor.author	Meredith, Sandra Allison	en_ZA
dc.date.accessioned	2014-07-28T18:19:16Z
dc.date.available	2014-07-28T18:19:16Z
dc.date.issued	2009	en_ZA
dc.identifier.citation	Meredith, S. 2009. The characterization of adaptor protein homologues in Plasmodium falciparum. University of Cape Town.	en_ZA
dc.identifier.uri	http://hdl.handle.net/11427/3291
dc.description	Includes abstract.
dc.description	Includes bibliographical references (leaves 148-171).
dc.description.abstract	Plasmodium falciparum is becoming increasingly more resistant to regular antimalarial drugs, making it necessary to identify novel drug candidates and drug targets. Components of the endocytic and secretory pathway in asexual stage parasites are attractive targets because they play a fundamental role in the normal processes of parasite metabolism. Adaptor protein complexes are components of protein coats that associate with transport vesicles of the endocytic and secretory pathways in mammalian cells. Homologues of several adaptor protein subunits are encoded by the parasite genome. The presence of these genes suggests that the parasite experiences clathrin-mediated transport processes. This study reports the cloning and characterization of selected malarial homologues of these adaptor proteins, namely three medium (μ) chain adaptin homologues and two sigma (σ) chains.	en_ZA
dc.language.iso	eng	en_ZA
dc.subject.other	Pharmacology	en_ZA
dc.title	The characterization of adaptor protein homologues in Plasmodium falciparum	en_ZA
dc.type	Doctoral Thesis
uct.type.publication	Research	en_ZA
uct.type.resource	Thesis	en_ZA
dc.publisher.institution	University of Cape Town
dc.publisher.faculty	Faculty of Health Sciences	en_ZA
dc.publisher.department	Division of Clinical Pharmacology	en_ZA
dc.type.qualificationlevel	Doctoral
dc.type.qualificationname	PhD	en_ZA
uct.type.filetype	Text
uct.type.filetype	Image
dc.identifier.apacitation	Meredith, S. A. (2009). <i>The characterization of adaptor protein homologues in Plasmodium falciparum</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology. Retrieved from http://hdl.handle.net/11427/3291	en_ZA
dc.identifier.chicagocitation	Meredith, Sandra Allison. <i>"The characterization of adaptor protein homologues in Plasmodium falciparum."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 2009. http://hdl.handle.net/11427/3291	en_ZA
dc.identifier.vancouvercitation	Meredith SA. The characterization of adaptor protein homologues in Plasmodium falciparum. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 2009 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3291	en_ZA
dc.identifier.ris	TY - Thesis / Dissertation AU - Meredith, Sandra Allison AB - Plasmodium falciparum is becoming increasingly more resistant to regular antimalarial drugs, making it necessary to identify novel drug candidates and drug targets. Components of the endocytic and secretory pathway in asexual stage parasites are attractive targets because they play a fundamental role in the normal processes of parasite metabolism. Adaptor protein complexes are components of protein coats that associate with transport vesicles of the endocytic and secretory pathways in mammalian cells. Homologues of several adaptor protein subunits are encoded by the parasite genome. The presence of these genes suggests that the parasite experiences clathrin-mediated transport processes. This study reports the cloning and characterization of selected malarial homologues of these adaptor proteins, namely three medium (μ) chain adaptin homologues and two sigma (σ) chains. DA - 2009 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - The characterization of adaptor protein homologues in Plasmodium falciparum TI - The characterization of adaptor protein homologues in Plasmodium falciparum UR - http://hdl.handle.net/11427/3291 ER -	en_ZA