Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections

 

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dc.contributor.advisor Maartens, Gary en_ZA
dc.contributor.advisor Cohen, Karen en_ZA
dc.contributor.author Gounden, Ronald en_ZA
dc.date.accessioned 2014-07-28T18:18:57Z
dc.date.available 2014-07-28T18:18:57Z
dc.date.issued 2009 en_ZA
dc.identifier.citation Gounden, R. 2009. Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/3282
dc.description Includes bibliographical references (leaves 42-47).
dc.description.abstract Background: Nosocomial infections due to multi-drug resistant Acinetobacter baumannii are often treated with colistin, but there are few data comparing its safety and effectiveness with other antimicrobials, particularly the aminoglycosides. Metbods: A retrospective cohort study of patients treated with colistin or tobramycin for A. baumannii infections in intensive care units (ICUs) at Groote Schuur hospital was performed. Colistin was used for A baumannii isolates which were resistant to all other available antimicrobials. Tobramycin was used when the organism was susceptible to this antimicrobial. We assessed and compared ICU mortality, nephrotoxicity and time to the first negative culture in the colistin and tobramycin groups. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Clinical Pharmacology en_ZA
dc.title Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections en_ZA
dc.type Master Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Clinical Pharmacology en_ZA
dc.type.qualificationlevel Masters
dc.type.qualificationname MMed en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Gounden, R. (2009). <i>Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology. Retrieved from http://hdl.handle.net/11427/3282 en_ZA
dc.identifier.chicagocitation Gounden, Ronald. <i>"Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 2009. http://hdl.handle.net/11427/3282 en_ZA
dc.identifier.vancouvercitation Gounden R. Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 2009 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3282 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Gounden, Ronald AB - Background: Nosocomial infections due to multi-drug resistant Acinetobacter baumannii are often treated with colistin, but there are few data comparing its safety and effectiveness with other antimicrobials, particularly the aminoglycosides. Metbods: A retrospective cohort study of patients treated with colistin or tobramycin for A. baumannii infections in intensive care units (ICUs) at Groote Schuur hospital was performed. Colistin was used for A baumannii isolates which were resistant to all other available antimicrobials. Tobramycin was used when the organism was susceptible to this antimicrobial. We assessed and compared ICU mortality, nephrotoxicity and time to the first negative culture in the colistin and tobramycin groups. DA - 2009 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections TI - Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections UR - http://hdl.handle.net/11427/3282 ER - en_ZA


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