Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors

 

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dc.contributor.advisor Collins, Malcolm en_ZA
dc.contributor.advisor Schwellnus, Martin en_ZA
dc.contributor.author Mokone, Gaonyadiwe George en_ZA
dc.date.accessioned 2014-07-28T18:17:33Z
dc.date.available 2014-07-28T18:17:33Z
dc.date.issued 2006 en_ZA
dc.identifier.citation Mokone, G. 2006. Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/3270
dc.description Includes bibliographical references.
dc.description.abstract This main purpose of this thesis was therefore to investigate whether any specific genes on the tip of the long arm of chromosome 9 were associated with Achilles tendon injuries, using a case-control study design. The specific objectives were: (i) to identify all genes located in the 9q32-q34.3 locus in close proximity to the ABO gene, that could be involved in tendon injuries (Chapter 2) and (ii) to investigate the possible association of the identified candidate genes (COL5A1 and TNC with both Achilles tendon rupture and chronic Achilles tendinopathy (Chapter 3 and 4) and (iii) finally to investigate the possible interaction of these two genes with tendon function, namely the muscle-tendon unit flexibility (chapter 5) and structure, namely the morphological changes of the Achilles tendon (Chapter 6). en_ZA
dc.language.iso eng en_ZA
dc.subject.other Human Biology en_ZA
dc.title Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors en_ZA
dc.type Doctoral Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Human Biology en_ZA
dc.type.qualificationlevel Doctoral
dc.type.qualificationname PhD en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Mokone, G. G. (2006). <i>Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology. Retrieved from http://hdl.handle.net/11427/3270 en_ZA
dc.identifier.chicagocitation Mokone, Gaonyadiwe George. <i>"Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2006. http://hdl.handle.net/11427/3270 en_ZA
dc.identifier.vancouvercitation Mokone GG. Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2006 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3270 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Mokone, Gaonyadiwe George AB - This main purpose of this thesis was therefore to investigate whether any specific genes on the tip of the long arm of chromosome 9 were associated with Achilles tendon injuries, using a case-control study design. The specific objectives were: (i) to identify all genes located in the 9q32-q34.3 locus in close proximity to the ABO gene, that could be involved in tendon injuries (Chapter 2) and (ii) to investigate the possible association of the identified candidate genes (COL5A1 and TNC with both Achilles tendon rupture and chronic Achilles tendinopathy (Chapter 3 and 4) and (iii) finally to investigate the possible interaction of these two genes with tendon function, namely the muscle-tendon unit flexibility (chapter 5) and structure, namely the morphological changes of the Achilles tendon (Chapter 6). DA - 2006 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2006 T1 - Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors TI - Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors UR - http://hdl.handle.net/11427/3270 ER - en_ZA


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