Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors
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| dc.contributor.advisor | Collins, Malcolm | en_ZA |
| dc.contributor.advisor | Schwellnus, Martin | en_ZA |
| dc.contributor.author |
Mokone, Gaonyadiwe George
|
en_ZA |
| dc.date.accessioned | 2014-07-28T18:17:33Z | |
| dc.date.available | 2014-07-28T18:17:33Z | |
| dc.date.issued | 2006 | en_ZA |
| dc.identifier.citation | Mokone, G. 2006. Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors. University of Cape Town. | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/3270 | |
| dc.description | Includes bibliographical references. | |
| dc.description.abstract | This main purpose of this thesis was therefore to investigate whether any specific genes on the tip of the long arm of chromosome 9 were associated with Achilles tendon injuries, using a case-control study design. The specific objectives were: (i) to identify all genes located in the 9q32-q34.3 locus in close proximity to the ABO gene, that could be involved in tendon injuries (Chapter 2) and (ii) to investigate the possible association of the identified candidate genes (COL5A1 and TNC with both Achilles tendon rupture and chronic Achilles tendinopathy (Chapter 3 and 4) and (iii) finally to investigate the possible interaction of these two genes with tendon function, namely the muscle-tendon unit flexibility (chapter 5) and structure, namely the morphological changes of the Achilles tendon (Chapter 6). | en_ZA |
| dc.language.iso | eng | en_ZA |
| dc.subject.other | Human Biology | en_ZA |
| dc.title | Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors | en_ZA |
| dc.type | Doctoral Thesis | |
| uct.type.publication | Research | en_ZA |
| uct.type.resource | Thesis | en_ZA |
| dc.publisher.institution | University of Cape Town | |
| dc.publisher.faculty | Faculty of Health Sciences | en_ZA |
| dc.publisher.department | Department of Human Biology | en_ZA |
| dc.type.qualificationlevel | Doctoral | |
| dc.type.qualificationname | PhD | en_ZA |
| uct.type.filetype | Text | |
| uct.type.filetype | Image | |
| dc.identifier.apacitation | Mokone, G. G. (2006). <i>Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology. Retrieved from http://hdl.handle.net/11427/3270 | en_ZA |
| dc.identifier.chicagocitation | Mokone, Gaonyadiwe George. <i>"Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2006. http://hdl.handle.net/11427/3270 | en_ZA |
| dc.identifier.vancouvercitation | Mokone GG. Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2006 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3270 | en_ZA |
| dc.identifier.ris | TY - Thesis / Dissertation AU - Mokone, Gaonyadiwe George AB - This main purpose of this thesis was therefore to investigate whether any specific genes on the tip of the long arm of chromosome 9 were associated with Achilles tendon injuries, using a case-control study design. The specific objectives were: (i) to identify all genes located in the 9q32-q34.3 locus in close proximity to the ABO gene, that could be involved in tendon injuries (Chapter 2) and (ii) to investigate the possible association of the identified candidate genes (COL5A1 and TNC with both Achilles tendon rupture and chronic Achilles tendinopathy (Chapter 3 and 4) and (iii) finally to investigate the possible interaction of these two genes with tendon function, namely the muscle-tendon unit flexibility (chapter 5) and structure, namely the morphological changes of the Achilles tendon (Chapter 6). DA - 2006 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2006 T1 - Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors TI - Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors UR - http://hdl.handle.net/11427/3270 ER - | en_ZA |
