Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women
JavaScript is disabled for your browser. Some features of this site may not work without it.
- OpenUCT Home
- →
- Theses / Dissertations
- →
- PhD / Doctoral
- →
- View Item
| dc.contributor.advisor | Goedecke, Julia | en_ZA |
| dc.contributor.advisor | Collins, Malcolm | en_ZA |
| dc.contributor.advisor | Van der Merwe, Lize | en_ZA |
| dc.contributor.author |
Joffe, Yael
|
en_ZA |
| dc.date.accessioned | 2014-07-28T18:16:55Z | |
| dc.date.available | 2014-07-28T18:16:55Z | |
| dc.date.issued | 2013 | en_ZA |
| dc.identifier.citation | Joffe, Y. 2013. Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women. University of Cape Town. | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/3253 | |
| dc.description | Includes abstract. | |
| dc.description | Includes bibliographical references. | |
| dc.description.abstract | The primary aim of the thesis was to investigate associations between TNFA (TNFA-308 G>A and -238 G>A) and IL-6 (-174 G>C, IVS3+281 G>T, IVS4+869 A>G) sequence variants and obesity and serum lipid concentrations in black and white SA women. This included identifying sequence variants in the IL-6 gene with a reported high heterozygosity in both the white and black SA populations (rs1554606 and sr2069845). Dietary intake data of adequate reporters was then included in the analysis to investigate whether dietary fatty acid intake modulated the interactions between the TNFA and IL-6 SNPs (TNFA -308 G>A and -238 G>A & IL-6 -174 G>C, IVS3+281 G>T, IVS4+869 A>G) and obesity, measures of adiposity and serum lipid concentrations, and whether interactions identified differed between black and white women. | en_ZA |
| dc.language.iso | eng | en_ZA |
| dc.subject.other | Human Biology | en_ZA |
| dc.title | Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women | en_ZA |
| dc.type | Doctoral Thesis | |
| uct.type.publication | Research | en_ZA |
| uct.type.resource | Thesis | en_ZA |
| dc.publisher.institution | University of Cape Town | |
| dc.publisher.faculty | Faculty of Health Sciences | en_ZA |
| dc.publisher.department | Department of Human Biology | en_ZA |
| dc.type.qualificationlevel | Doctoral | |
| dc.type.qualificationname | PhD | en_ZA |
| uct.type.filetype | Text | |
| uct.type.filetype | Image | |
| dc.identifier.apacitation | Joffe, Y. (2013). <i>Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology. Retrieved from http://hdl.handle.net/11427/3253 | en_ZA |
| dc.identifier.chicagocitation | Joffe, Yael. <i>"Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2013. http://hdl.handle.net/11427/3253 | en_ZA |
| dc.identifier.vancouvercitation | Joffe Y. Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3253 | en_ZA |
| dc.identifier.ris | TY - Thesis / Dissertation AU - Joffe, Yael AB - The primary aim of the thesis was to investigate associations between TNFA (TNFA-308 G>A and -238 G>A) and IL-6 (-174 G>C, IVS3+281 G>T, IVS4+869 A>G) sequence variants and obesity and serum lipid concentrations in black and white SA women. This included identifying sequence variants in the IL-6 gene with a reported high heterozygosity in both the white and black SA populations (rs1554606 and sr2069845). Dietary intake data of adequate reporters was then included in the analysis to investigate whether dietary fatty acid intake modulated the interactions between the TNFA and IL-6 SNPs (TNFA -308 G>A and -238 G>A & IL-6 -174 G>C, IVS3+281 G>T, IVS4+869 A>G) and obesity, measures of adiposity and serum lipid concentrations, and whether interactions identified differed between black and white women. DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women TI - Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women UR - http://hdl.handle.net/11427/3253 ER - | en_ZA |
