The expression and functional analysis of neurite outgrowth inhibitors in the nervous system of Xenopus laevis
Doctoral Thesis
2007
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University of Cape Town
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Abstract
Generally, the factors contributing to success or failure of axon regeneration lie in the intrinsic properties of the injured neurons, as well as the surrounding microenvironment of the transected axon. Mammalian neurons may lack the intrinsic ability to survive after trauma, or to re-express genes required for axonal regrowth. Moreover, several proteins inhibitory to neurite growth, such as Tenascin-R (TN-R) and Nogo-A, have been identified in mammals. These proteins are associated with oligodendrocytes and myelin and are considered major inhibitory components of the CNS environment.
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Includes bibliographical references (leaves 115-128).
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Hsu, N. 2007. The expression and functional analysis of neurite outgrowth inhibitors in the nervous system of Xenopus laevis. University of Cape Town.