Corticotropin-releasing factor and acute post-operative gut function in truamatic abdominal injury and elective abdominal surgery

 

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dc.contributor.advisor Kidson, Sue en_ZA
dc.contributor.author Hill, Lauren en_ZA
dc.date.accessioned 2014-07-28T18:16:46Z
dc.date.available 2014-07-28T18:16:46Z
dc.date.issued 2009 en_ZA
dc.identifier.citation Hill, L. 2009. Corticotropin-releasing factor and acute post-operative gut function in truamatic abdominal injury and elective abdominal surgery. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/3247
dc.description Includes abstract.
dc.description Includes bibliographical references (leaves 108-128).
dc.description.abstract Shocked trauma patients in the Intensive Care Unit undergo a powerful, neuro-endocrine stress response driven by cytokine release and the hypothalamic-pituitary-adrenal axis. The response is activated under stress by corticotropin-releasing factor (CRF), the well-known 41 amino acid peptide neuro-hormone. Evidence from animal and human studies suggests that peripheral CRF is present in the gastrointestinal tract and associated with inflammatory changes. Critically ill patients frequently display somewhat unexplained gastrointestinal dysfunction including delayed gastric emptying, ileus and increased bowel permeability. The aim of the study was to investigate the role of CRF in critically ill adults with traumatic abdominal injury compared with elective surgical patients, and describe any association of CRF levels with alterations in acute post-operative gastrointestinal function. Eight patients with haemorrhagic shock following penetrating abdominal injury and seventeen patients undergoing elective surgery for hepato-biliary disease were studied for serial plasma and intestinal tissue CRF levels using radio-immunoassay. A RT-PCR technique was used to detect mRNA for CRF in intestinal tissue. Light microscopy was used to determine the quantity and distribution of mast cells in intestinal tissue. Post-operative gastric emptying was assessed using the paracetamol absorption test and intestinal permeability by measuring urinary lactulose:mannitol ratios following a bolus of these sugars. The study was approved by University of Cape Town Human Research Ethics Committee. Informed consent (retrospectively in the case of the trauma patients), was obtained from all subjects. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Physiology en_ZA
dc.title Corticotropin-releasing factor and acute post-operative gut function in truamatic abdominal injury and elective abdominal surgery en_ZA
dc.type Thesis / Dissertation en_ZA
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Human Biology en_ZA
dc.type.qualificationlevel Doctoral en_ZA
dc.type.qualificationname PhD en_ZA
uct.type.filetype Text


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