Specific diagnosis for effective treatment of neuroblastomas and pulmonary neuroendocrine tumors through transcriptional profiling-based interpretation of cellular development

 

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dc.contributor.advisor Neuman, Toomas en_ZA
dc.contributor.author Smit, Marithea en_ZA
dc.date.accessioned 2014-07-28T18:15:27Z
dc.date.available 2014-07-28T18:15:27Z
dc.date.issued 2002 en_ZA
dc.identifier.citation Smit, M. 2002. Specific diagnosis for effective treatment of neuroblastomas and pulmonary neuroendocrine tumors through transcriptional profiling-based interpretation of cellular development. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/3203
dc.description Bibliography: leaves 139-178.
dc.description.abstract Induction of tumor differentiation through manipulation of regulatory genes is a relatively unexplored area of cancer therapy, however, it might suggest and additional approach for tumour-specific treatment. Therefore, in view of this idea, the present study hypothesized that neuroblastomas (NBs) and pulmonary neuroendocrine tumors (NETs), which are neoplasms of neural origin, are molecularly different based on their expression of regulatory genes and that exposure to extrinsic factors will alter their growth potential. Using reverse-transcription polymerase chain reaction (RT-PCR) analysis, the present study compared the expression of about 50 regulatory genes that are expressed at early stages of neurogenesis in five human NBs and NETs, also upon GDNF/TGF-β1 and retinoic acid (RA) treatment. According to our results, individual NBs and NETs reflected a certain stage of neural development characterized by their expression of discrete sets of regulatory genes. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Human Biology en_ZA
dc.title Specific diagnosis for effective treatment of neuroblastomas and pulmonary neuroendocrine tumors through transcriptional profiling-based interpretation of cellular development en_ZA
dc.type Doctoral Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Human Biology en_ZA
dc.type.qualificationlevel Doctoral
dc.type.qualificationname PhD en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Smit, M. (2002). <i>Specific diagnosis for effective treatment of neuroblastomas and pulmonary neuroendocrine tumors through transcriptional profiling-based interpretation of cellular development</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology. Retrieved from http://hdl.handle.net/11427/3203 en_ZA
dc.identifier.chicagocitation Smit, Marithea. <i>"Specific diagnosis for effective treatment of neuroblastomas and pulmonary neuroendocrine tumors through transcriptional profiling-based interpretation of cellular development."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2002. http://hdl.handle.net/11427/3203 en_ZA
dc.identifier.vancouvercitation Smit M. Specific diagnosis for effective treatment of neuroblastomas and pulmonary neuroendocrine tumors through transcriptional profiling-based interpretation of cellular development. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2002 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3203 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Smit, Marithea AB - Induction of tumor differentiation through manipulation of regulatory genes is a relatively unexplored area of cancer therapy, however, it might suggest and additional approach for tumour-specific treatment. Therefore, in view of this idea, the present study hypothesized that neuroblastomas (NBs) and pulmonary neuroendocrine tumors (NETs), which are neoplasms of neural origin, are molecularly different based on their expression of regulatory genes and that exposure to extrinsic factors will alter their growth potential. Using reverse-transcription polymerase chain reaction (RT-PCR) analysis, the present study compared the expression of about 50 regulatory genes that are expressed at early stages of neurogenesis in five human NBs and NETs, also upon GDNF/TGF-β1 and retinoic acid (RA) treatment. According to our results, individual NBs and NETs reflected a certain stage of neural development characterized by their expression of discrete sets of regulatory genes. DA - 2002 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2002 T1 - Specific diagnosis for effective treatment of neuroblastomas and pulmonary neuroendocrine tumors through transcriptional profiling-based interpretation of cellular development TI - Specific diagnosis for effective treatment of neuroblastomas and pulmonary neuroendocrine tumors through transcriptional profiling-based interpretation of cellular development UR - http://hdl.handle.net/11427/3203 ER - en_ZA


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