Genetic risk factors for anterior cruciate ligament ruptures
Doctoral Thesis
2009
Permanent link to this Item
Authors
Journal Title
Link to Journal
Journal ISSN
Volume Title
Publisher
Publisher
University of Cape Town
Department
Faculty
License
Series
Abstract
The primary aim of this thesis was to identify candidate genes that may be associated with ACL ruptures, and then use a genetic association approach following a case-control study design to identify specific sequence variants (single nucleotide polymorphisms, SNPs) within these candidate genes which may predispose individuals to ACL ruptures. Candidate genes (COL1A1, COL5A1 and COL12A1) were selected based on the biological function of their encoded proteins (type I, type V and type XII collagen respectively) within the basic structural and functional unit of ligaments, namely the collagen microfibril.
Description
Includes abstract.
Includes bibliographical references (p. 197-215).
Keywords
Reference:
Posthumus, M. 2009. Genetic risk factors for anterior cruciate ligament ruptures. University of Cape Town.