Altered protein expression patterns in oesophageal cancer
Doctoral Thesis
2009
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University of Cape Town
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Abstract
Oesophageal squamous cell carcinoma presents a significant health burden in South Africa. It is one of the most common causes of cancer-related mortality of South African black males, as a result of its asymptomatic progression leading to late diagnosis and poor prognosis. The aim of this study was to identify membrane or membrane-associated proteins that are expressed at different levels in oesophageal tumour tissue when compared to normal tissue. The identification of such proteins would be an important step towards the development of better diagnostic and therapeutic strategies for this disease. Two proteomic approaches, were employed to identify differentially expressed proteins.
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Includes abstract.
Includes bibliographical references (leaves 125-143).
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Zemanay, W. 2009. Altered protein expression patterns in oesophageal cancer. University of Cape Town.