Identification of signalling pathways regulating TBX2 gene expression and its target genes

 

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dc.contributor.advisor Prince, Sharon en_ZA
dc.contributor.advisor Parker, M I en_ZA
dc.contributor.author Teng, Huajian en_ZA
dc.date.accessioned 2014-07-28T14:56:00Z
dc.date.available 2014-07-28T14:56:00Z
dc.date.issued 2008 en_ZA
dc.identifier.citation Teng, H. 2008. Identification of signalling pathways regulating TBX2 gene expression and its target genes. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/3151
dc.description Includes abstract.
dc.description Includes bibliographical references (leaves 83-97).
dc.description.abstract Members of the T-box family of transcription factors provide an important link between development and cancer. T-box factors play critical roles in embryonic development and results from recent studies suggest that they function in controlling cell cycle progression and also in the genesis of cancer. Importantly, the T-box factors Tbx2 and Tbx3 are overexpressed in several cancers including melanoma, small cell lung carcinoma, breast, pancreatic, liver and bladder cancers and can suppress senescence, a cellular process which serves as a barrier to cancer development. However, the precise role of most T-box factors is poorly defined, in part, because their target genes are still poorly characterised and very little is known of the signalling pathways that regulate their expression and activity. The broad aim of this study was therefore to contribute towards the identification of Tbx2 target genes as well as to identify signalling pathways that regulate TBX2 expression. The specific aims were thus to (1) investigate the regulation of type1 collagen gene expression by Tbx2; (2) clone the human TBX2 regulatory region and to identify cis-acting elements involved in the basal transcription of the TBX2 gene and (3) investigate the regulation of TBX2 gene expression by signalling pathways. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Medical Biochemistry en_ZA
dc.title Identification of signalling pathways regulating TBX2 gene expression and its target genes en_ZA
dc.type Doctoral Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Medical Biochemistry en_ZA
dc.type.qualificationlevel Doctoral
dc.type.qualificationname PhD en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Teng, H. (2008). <i>Identification of signalling pathways regulating TBX2 gene expression and its target genes</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry. Retrieved from http://hdl.handle.net/11427/3151 en_ZA
dc.identifier.chicagocitation Teng, Huajian. <i>"Identification of signalling pathways regulating TBX2 gene expression and its target genes."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2008. http://hdl.handle.net/11427/3151 en_ZA
dc.identifier.vancouvercitation Teng H. Identification of signalling pathways regulating TBX2 gene expression and its target genes. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2008 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3151 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Teng, Huajian AB - Members of the T-box family of transcription factors provide an important link between development and cancer. T-box factors play critical roles in embryonic development and results from recent studies suggest that they function in controlling cell cycle progression and also in the genesis of cancer. Importantly, the T-box factors Tbx2 and Tbx3 are overexpressed in several cancers including melanoma, small cell lung carcinoma, breast, pancreatic, liver and bladder cancers and can suppress senescence, a cellular process which serves as a barrier to cancer development. However, the precise role of most T-box factors is poorly defined, in part, because their target genes are still poorly characterised and very little is known of the signalling pathways that regulate their expression and activity. The broad aim of this study was therefore to contribute towards the identification of Tbx2 target genes as well as to identify signalling pathways that regulate TBX2 expression. The specific aims were thus to (1) investigate the regulation of type1 collagen gene expression by Tbx2; (2) clone the human TBX2 regulatory region and to identify cis-acting elements involved in the basal transcription of the TBX2 gene and (3) investigate the regulation of TBX2 gene expression by signalling pathways. DA - 2008 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - Identification of signalling pathways regulating TBX2 gene expression and its target genes TI - Identification of signalling pathways regulating TBX2 gene expression and its target genes UR - http://hdl.handle.net/11427/3151 ER - en_ZA


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