Identification of genetic polymorphisms associated with oesophageal squamous cell carcinoma risk in South Africa

Doctoral Thesis

2013

Permanent link to this Item
http://hdl.handle.net/11427/3139
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thesis_hsf_2013_matejcic_m.pdf (3.54 MB)
Authors
Matejcic, Marco
Supervisors
Parker, M Iqbal
Mathew, Chris
Journal Title
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Volume Title
Publisher
Publisher

University of Cape Town

Department
Division of Medical Biochemistry
Faculty
Faculty of Health Sciences
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Abstract
Oesophageal squamous cell carcinoma (OSCC) is a complex disease, determined by the interaction of genetic factors with environmental risk factors. In South Africa, OSCC is a major malignancy occurring with high incidence in the Black and Mixed Ancestry populations. Previous studies by our research group have reported that genetic polymorphism of xenobiotic metabolizing enzymes influence greatly the detoxification of tobacco-related carcinogens in vivo, and may therefore have an important role in determining susceptibility to oesophageal cancer.
Description

Includes abstract.


Includes bibliographical references.

Keywords
Medical Biochemistry

Reference:

Matejcic, M. 2013. Identification of genetic polymorphisms associated with oesophageal squamous cell carcinoma risk in South Africa. University of Cape Town.

Collections
PhD / Doctoral