Spatial and temporal regulation of IL4Rα expression

Doctoral Thesis

2008

Permanent link to this Item
http://hdl.handle.net/11427/3117
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thesis_hsf_2008_smith_e_m.pdf (3.32 MB)
Authors
Smith, Elizabeth M
Supervisors
Brombacher, Frank
Horsnell, William
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University of Cape Town

Department
Division of Immunology
Faculty
Faculty of Health Sciences
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Abstract
In this study, we generated a new mouse model, which allows both inducible and cell-specific deletion and reconstitution of IL-IL4Rα expression. This model has the potential to add a new dimension to our understanding of IL4Rα biology. This has been achieved by using the established Tet System (Goosen and Bujard, 1992) where the crossing of two complementary transgenic mouse lines enable the generation of the final double transgenic model. The first line expresses the transactivator, tTA, from the Tet-Off expression cassette driven by the Vav hemapoeitic specific promoter (Wiesner et al., 2005).
Description

Includes abstract.

Keywords
Immunology

Reference:

Smith, E. 2008. Spatial and temporal regulation of IL4Rα expression. University of Cape Town.

Collections
PhD / Doctoral