Lymphocyte-specific reconstitution of IL-4Ra-deficient mice : characterization and infectious disease studies
Doctoral Thesis
2006
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University of Cape Town
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Abstract
Lymphocyte-specific reconstitution of IL-4Ra was recently established by intercrossing lymphocyte-specific human IL-R4a transgenic mice with mIL-4Ra-deficient mice. Human IL-4Ra may bind to mouse yc resulting in a chimeric receptor specific for human IL-4 but not mouse IL-4. This provides us with and inducible IL-4 system. The aim of this study was to investigate in vitro and in vivo characteristics of our novel hlL-4Ra Tg/mIL-4Ra+/- mouse model.
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Includes bibliographical references (leaves 114-142).
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Myburgh, E. 2006. Lymphocyte-specific reconstitution of IL-4Ra-deficient mice : characterization and infectious disease studies. University of Cape Town.