Lymphocyte-specific reconstitution of IL-4Ra-deficient mice : characterization and infectious disease studies

Doctoral Thesis

2006

Permanent link to this Item
http://hdl.handle.net/11427/3114
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thesis_hsf_2006_myburgh_e (1).pdf (10.74 MB)
Authors
Myburgh, Elmarie
Supervisors
Brombacher, Frank
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University of Cape Town

Department
Division of Immunology
Faculty
Faculty of Health Sciences
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Abstract
Lymphocyte-specific reconstitution of IL-4Ra was recently established by intercrossing lymphocyte-specific human IL-R4a transgenic mice with mIL-4Ra-deficient mice. Human IL-4Ra may bind to mouse yc resulting in a chimeric receptor specific for human IL-4 but not mouse IL-4. This provides us with and inducible IL-4 system. The aim of this study was to investigate in vitro and in vivo characteristics of our novel hlL-4Ra Tg/mIL-4Ra+/- mouse model.
Description

Includes bibliographical references (leaves 114-142).

Keywords
Immunology

Reference:

Myburgh, E. 2006. Lymphocyte-specific reconstitution of IL-4Ra-deficient mice : characterization and infectious disease studies. University of Cape Town.

Collections
PhD / Doctoral