The agreement between fasting glucose and markers of chronic glycaemic exposure in individuals with and without chronic kidney disease: a cross-sectional study

 

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dc.contributor.author George, Cindy
dc.contributor.author Matsha, Tandi E
dc.contributor.author Korf, Marizna
dc.contributor.author Zemlin, Annalise E
dc.contributor.author Erasmus, Rajiv T
dc.contributor.author Kengne, Andre P
dc.date.accessioned 2020-02-11T13:09:43Z
dc.date.available 2020-02-11T13:09:43Z
dc.date.issued 2020-01-30
dc.identifier.citation George, C., Matsha, T. E., Korf, M., Zemlin, A. E., Erasmus, R. T., & Kengne, A. P. (2020). The agreement between fasting glucose and markers of chronic glycaemic exposure in individuals with and without chronic kidney disease: a cross-sectional study. BMC nephrology, 21(1), 32.
dc.identifier.uri https://doi.org/10.1186/s12882-020-1697-z
dc.identifier.uri http://hdl.handle.net/11427/31040
dc.description.abstract Abstract Background To assess whether the agreement between fasting glucose and glycated proteins is affected by chronic kidney disease (CKD) in a community-based sample of 1621 mixed-ancestry South Africans. Methods CKD was defined as an estimated glomerular filtration rate < 60 ml/min/1.73 m2. Fasting plasma glucose and haemoglobin A1c (HbA1c) concentrations were measured by enzymatic hexokinase method and high-performance liquid chromatography, respectively, with fructosamine and glycated albumin measured by immunoturbidimetry and enzymatic method, respectively. Results Of those with CKD (n = 96), 79, 16 and 5% where in stages 3, 4 and 5, respectively. Those with CKD had higher levels of HbA1c (6.2 vs. 5.7%; p < 0.0001), glycated albumin (15.0 vs. 13.0%; p < 0.0001) and fructosamine levels (269.7 vs. 236.4 μmol/l; p < 0.0001), compared to those without CKD. Higher fasting glucose levels were associated with higher HbA1c, glycated albumin and fructosamine, independent of age, gender, and CKD. However, the association with HbA1c and glycated albumin differed by CKD status, at the upper concentrations of the respective markers (interaction term for both: p ≤ 0.095). Conclusion Our results suggest that although HbA1c and glycated albumin perform acceptably under conditions of normoglycaemia, these markers correlate less well with blood glucose levels in people with CKD who are not on dialysis.
dc.subject Chronic kidney disease
dc.subject Fructosamine
dc.subject Glucose tolerance
dc.subject Glycated albumin
dc.subject Haemoglobin A1c
dc.title The agreement between fasting glucose and markers of chronic glycaemic exposure in individuals with and without chronic kidney disease: a cross-sectional study
dc.type Journal Article
dc.date.updated 2020-02-02T04:18:16Z
dc.language.rfc3066 en
dc.rights.holder The Author(s).
dc.identifier.apacitation George, C., Matsha, T. E., Korf, M., Zemlin, A. E., Erasmus, R. T., & Kengne, A. P. (2020). The agreement between fasting glucose and markers of chronic glycaemic exposure in individuals with and without chronic kidney disease: a cross-sectional study. http://hdl.handle.net/11427/31040 en_ZA
dc.identifier.chicagocitation George, Cindy, Tandi E Matsha, Marizna Korf, Annalise E Zemlin, Rajiv T Erasmus, and Andre P Kengne "The agreement between fasting glucose and markers of chronic glycaemic exposure in individuals with and without chronic kidney disease: a cross-sectional study." (2020) http://hdl.handle.net/11427/31040 en_ZA
dc.identifier.vancouvercitation George C, Matsha TE, Korf M, Zemlin AE, Erasmus RT, Kengne AP. The agreement between fasting glucose and markers of chronic glycaemic exposure in individuals with and without chronic kidney disease: a cross-sectional study. 2020; http://hdl.handle.net/11427/31040. en_ZA
dc.identifier.ris TY - AU - George, Cindy AU - Matsha, Tandi E AU - Korf, Marizna AU - Zemlin, Annalise E AU - Erasmus, Rajiv T AU - Kengne, Andre P AB - Abstract Background To assess whether the agreement between fasting glucose and glycated proteins is affected by chronic kidney disease (CKD) in a community-based sample of 1621 mixed-ancestry South Africans. Methods CKD was defined as an estimated glomerular filtration rate < 60 ml/min/1.73 m2. Fasting plasma glucose and haemoglobin A1c (HbA1c) concentrations were measured by enzymatic hexokinase method and high-performance liquid chromatography, respectively, with fructosamine and glycated albumin measured by immunoturbidimetry and enzymatic method, respectively. Results Of those with CKD (n = 96), 79, 16 and 5% where in stages 3, 4 and 5, respectively. Those with CKD had higher levels of HbA1c (6.2 vs. 5.7%; p < 0.0001), glycated albumin (15.0 vs. 13.0%; p < 0.0001) and fructosamine levels (269.7 vs. 236.4 μmol/l; p < 0.0001), compared to those without CKD. Higher fasting glucose levels were associated with higher HbA1c, glycated albumin and fructosamine, independent of age, gender, and CKD. However, the association with HbA1c and glycated albumin differed by CKD status, at the upper concentrations of the respective markers (interaction term for both: p ≤ 0.095). Conclusion Our results suggest that although HbA1c and glycated albumin perform acceptably under conditions of normoglycaemia, these markers correlate less well with blood glucose levels in people with CKD who are not on dialysis. DA - 2020-01-30 DB - OpenUCT DP - University of Cape Town KW - Chronic kidney disease KW - Fructosamine KW - Glucose tolerance KW - Glycated albumin KW - Haemoglobin A1c LK - https://open.uct.ac.za PY - 2020 T1 - The agreement between fasting glucose and markers of chronic glycaemic exposure in individuals with and without chronic kidney disease: a cross-sectional study TI - The agreement between fasting glucose and markers of chronic glycaemic exposure in individuals with and without chronic kidney disease: a cross-sectional study UR - http://hdl.handle.net/11427/31040 ER - en_ZA


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