Effect of selenium on cadmium-induced oxidative stress and esterase activity in rat organs

 

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dc.contributor.author Dzobo, Kevin
dc.contributor.author Naik, Yogeshkumar V
dc.date.accessioned 2018-11-20T13:43:49Z
dc.date.available 2018-11-20T13:43:49Z
dc.date.issued 2013
dc.identifier http://dx.doi.org/10.1590/ sajs.2013/965
dc.identifier.citation Dzobo, K., & Naik, Y. S. (2013). Effect of selenium on cadmium-induced oxidative stress and esterase activity in rat organs. South African Journal of Science, 109(5-6), 01-08.
dc.identifier.uri http://hdl.handle.net/11427/29072
dc.description.abstract Metal toxicity is a threat mainly in the industrialised world where industry discharges many toxic metals into the environment. We investigated the effects of two metals - cadmium and selenium - on the cytosolic antioxidant enzymes and esterases in the liver, kidneys and testes of rats. Male Sprague-Dawley rats( N =28) were divided equally into four groups: control, cadmium, selenium and cadmium/selenium. Salts of the metals were administered intraperitoneally for 15 days. In the liver, cadmium treatment (1.67 mg/kg per day) resulted in a decrease in catalase activity and an increase superoxide dismutase (SOD) activity. Selenium treatment (0.23 mg/kg per day) resulted in increases in glutathione s-transferase, catalase and DT-diaphorase activities. Treatment with both cadmium and selenium resulted in an increase in glutathione peroxidase (GPx) activity. Esterase activities were significantly lower in the presence of cadmium. In the kidney, cadmium treatment caused a decrease in catalase, DT-diaphorase, and SOD activities and selenium supplementation reversed the cadmium-induced decrease in these enzyme activities. Selenium treatment increased catalase and SOD activities in the kidney. In the testis, cadmium treatment decreased GPx and SOD activities, but at the same time increased catalase and DT-diaphorase activities. Esterase activities increased in the presence of selenium in both the kidney and testis. These results suggest that selenium might be toxic to the liver while at the same time play a protective role against cadmium-induced oxidative stress and toxicity in the kidney and testis.
dc.source South African Journal of Science
dc.source.uri https://www.sajs.co.za/
dc.subject.other selenium
dc.subject.other cadmium
dc.subject.other antioxidant
dc.subject.other oxidative stress
dc.subject.other rat organs
dc.title Effect of selenium on cadmium-induced oxidative stress and esterase activity in rat organs
dc.date.updated 2018-11-20T13:41:44Z
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences
dc.publisher.department Department of Clinical Laboratory Sciences
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