Nanomedicine for drug delivery in South Africa: a protocol for systematic review

 

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dc.contributor.author Saidi, Trust
dc.contributor.author Fortuin, Jill
dc.contributor.author Douglas, Tania S
dc.date.accessioned 2018-10-08T10:11:07Z
dc.date.available 2018-10-08T10:11:07Z
dc.date.issued 2018-10-06
dc.identifier.citation Systematic Reviews. 2018 Oct 06;7(1):154
dc.identifier.uri https://doi.org/10.1186/s13643-018-0823-5
dc.identifier.uri http://hdl.handle.net/11427/28917
dc.description.abstract Background: The emergence of nanomedicine in the past decade has changed the landscape of disease diagnosis and treatment. Nanomedicine makes use of nanostructures for applications in different fields of medicine, including drug delivery, biosensors, neuro-electronic interfaces, in vivo imaging, and cell-specific molecular interactions. Despite its relative infancy, nanomedicine has generated a significant body of research as evidenced by peer reviewed literature and several patents. This proposed systematic review will focus specifically on drug delivery systems in which nanoparticles are used to enhance the pharmacological and therapeutic properties of drugs. The strength of nanoparticulate drug delivery systems is their ability to alter the pharmacokinetics and bio-distribution of drugs. Globally, the discourse on nanomedicine is dominated by research being done in the developed countries of Europe and in the United States of America. Less attention has been given to the applications of nanomedicine in developing countries, particularly Africa. There is dearth of information on the applications of nanomedicine in terms of drug delivery with particular reference to which diseases are being targeted generally in Africa. The review will describe the specific diseases that are being targeted and the progress being made in South Africa, with a view to determining whether the applications of nanomedicine are being appropriated to address the context-specific challenges in this country or if they mimic what is being done globally. Methods: Keywords related to nanomedicine and drug delivery will be combined to build a search strategy for each of the following databases: PubMed, Cochrane Library (including Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Database of Systematic Reviews, Cochrane Methodology Register), Google Scholar, NHS Health Technology Assessment Database and Web of Science. We will also check reference lists of included studies for other eligible reports and search unpublished data. To ensure that the search is comprehensive, grey literature will be searched extensively. Literature to be included will have nanomedicine in drug delivery as the primary application and report on the specific diseases that are targeted in South Africa. Two authors will independently screen the search output, select studies and extract data; discrepancies will be resolved by consensus and discussion. When no consensus is reached, the third author will be consulted. Discussion: The systematic review will inform the government, policy-makers, investors, health professionals, scientists, and engineers about the applications of nanomedicine in drug delivery. In particular, it will identify the diseases targeted by the application of nanomedicine for drug delivery and the progress being made in South Africa as the disease burden of this country differs from that of developed countries where nanomedicine has been widely used for drug delivery. Systematic review registration PROSPERO CRD42017057388
dc.language.iso en
dc.publisher BioMed Central
dc.source Systematic Reviews
dc.source.uri https://systematicreviewsjournal.biomedcentral.com/
dc.subject.other Nano
dc.subject.other Nanomedicine
dc.subject.other Nanotechnology
dc.subject.other Drug delivery
dc.subject.other Diseases
dc.title Nanomedicine for drug delivery in South Africa: a protocol for systematic review
dc.type Journal Article
dc.date.updated 2018-10-07T03:19:33Z
dc.rights.holder The Author(s).
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Biomedical Engineering en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Saidi, T., Fortuin, J., & Douglas, T. S. (2018). Nanomedicine for drug delivery in South Africa: a protocol for systematic review. <i>Systematic Reviews</i>, http://hdl.handle.net/11427/28917 en_ZA
dc.identifier.chicagocitation Saidi, Trust, Jill Fortuin, and Tania S Douglas "Nanomedicine for drug delivery in South Africa: a protocol for systematic review." <i>Systematic Reviews</i> (2018) http://hdl.handle.net/11427/28917 en_ZA
dc.identifier.vancouvercitation Saidi T, Fortuin J, Douglas TS. Nanomedicine for drug delivery in South Africa: a protocol for systematic review. Systematic Reviews. 2018; http://hdl.handle.net/11427/28917. en_ZA
dc.identifier.ris TY - Journal Article AU - Saidi, Trust AU - Fortuin, Jill AU - Douglas, Tania S AB - Background: The emergence of nanomedicine in the past decade has changed the landscape of disease diagnosis and treatment. Nanomedicine makes use of nanostructures for applications in different fields of medicine, including drug delivery, biosensors, neuro-electronic interfaces, in vivo imaging, and cell-specific molecular interactions. Despite its relative infancy, nanomedicine has generated a significant body of research as evidenced by peer reviewed literature and several patents. This proposed systematic review will focus specifically on drug delivery systems in which nanoparticles are used to enhance the pharmacological and therapeutic properties of drugs. The strength of nanoparticulate drug delivery systems is their ability to alter the pharmacokinetics and bio-distribution of drugs. Globally, the discourse on nanomedicine is dominated by research being done in the developed countries of Europe and in the United States of America. Less attention has been given to the applications of nanomedicine in developing countries, particularly Africa. There is dearth of information on the applications of nanomedicine in terms of drug delivery with particular reference to which diseases are being targeted generally in Africa. The review will describe the specific diseases that are being targeted and the progress being made in South Africa, with a view to determining whether the applications of nanomedicine are being appropriated to address the context-specific challenges in this country or if they mimic what is being done globally. Methods: Keywords related to nanomedicine and drug delivery will be combined to build a search strategy for each of the following databases: PubMed, Cochrane Library (including Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Database of Systematic Reviews, Cochrane Methodology Register), Google Scholar, NHS Health Technology Assessment Database and Web of Science. We will also check reference lists of included studies for other eligible reports and search unpublished data. To ensure that the search is comprehensive, grey literature will be searched extensively. Literature to be included will have nanomedicine in drug delivery as the primary application and report on the specific diseases that are targeted in South Africa. Two authors will independently screen the search output, select studies and extract data; discrepancies will be resolved by consensus and discussion. When no consensus is reached, the third author will be consulted. Discussion: The systematic review will inform the government, policy-makers, investors, health professionals, scientists, and engineers about the applications of nanomedicine in drug delivery. In particular, it will identify the diseases targeted by the application of nanomedicine for drug delivery and the progress being made in South Africa as the disease burden of this country differs from that of developed countries where nanomedicine has been widely used for drug delivery. Systematic review registration PROSPERO CRD42017057388 DA - 2018-10-06 DB - OpenUCT DP - University of Cape Town J1 - Systematic Reviews LK - https://open.uct.ac.za PB - University of Cape Town PY - 2018 T1 - Nanomedicine for drug delivery in South Africa: a protocol for systematic review TI - Nanomedicine for drug delivery in South Africa: a protocol for systematic review UR - http://hdl.handle.net/11427/28917 ER - en_ZA


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