Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial

 

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dc.contributor.author Chingono, R
dc.contributor.author Mebrahtu, H
dc.contributor.author Mupambireyi, Z
dc.contributor.author Simms, V
dc.contributor.author Weiss, H A
dc.contributor.author Ndlovu, P
dc.contributor.author Charasika, F
dc.contributor.author Tomlinson, M
dc.contributor.author Cluver, L D
dc.contributor.author Cowan, F M
dc.contributor.author Sherr, L
dc.date.accessioned 2018-07-17T10:53:05Z
dc.date.available 2018-07-17T10:53:05Z
dc.date.issued 2018-07-09
dc.identifier.citation Chingono, R., Mebrahtu, H., Mupambireyi, Z., Simms, V., Weiss, H. A., Ndlovu, P., ... & Sherr, L. (2018). Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial. BMC pediatrics, 18(1), 222.
dc.identifier.uri https://doi.org/10.1186/s12887-018-1201-0
dc.identifier.uri http://hdl.handle.net/11427/28307
dc.description.abstract Background HIV infection in a family may affect optimum child development. Our hypothesis is that child development outcomes among HIV-exposed infants will be improved through a complex early childhood stimulation (ECS) programme, and income and loans saving programme for HIV positive parents. Methods The study was a cluster-randomized controlled trial in 30 clinic sites in two districts in Zimbabwe. Clinics were randomised in a 1:1 allocation ratio to the Child Health Intervention for Development Outcomes (CHIDO) intervention or Ministry of Health standard care. The CHIDO intervention comprises three elements: a group ECS parenting programme, an internal savings and lending scheme (ISALS) and case-management home visits by village health workers. The intervention was aimed at caregiver-child dyads (child aged 0–24 months) where the infant was HIV exposed or infected. The primary outcomes were cognitive development (assessed by the Mullen Scales of Early Learning) and retention of the child in HIV care, at 12 months after enrolment. A comprehensive process evaluation was conducted. Discussion The results of this cluster-randomised trial will provide important information regarding the effects of multi-component interventions in mitigating developmental delays in HIV-exposed infants living in resource-limited environments. Trial registration This trial is registered with the Pan African Clinical Trials Registry ( www.pactr.org ), registration number PACTR201701001387209; the trial was registered on 16th January 2017 (retrospectively registered).
dc.language.iso en
dc.publisher BioMed Central
dc.source BMC Pediatrics
dc.source.uri https://bmcpediatr.biomedcentral.com/
dc.subject.other Early childhood stimulation
dc.subject.other Internal savings and lending scheme
dc.subject.other Case management
dc.subject.other HIV exposed infants
dc.subject.other Zimbabwe
dc.title Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial
dc.type Journal Article
dc.date.updated 2018-07-15T03:27:20Z
dc.rights.holder The Author(s).
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Humanities en_ZA
dc.publisher.department Aids and Society Research Unit en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Chingono, R., Mebrahtu, H., Mupambireyi, Z., Simms, V., Weiss, H. A., Ndlovu, P., ... Sherr, L. (2018). Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial. <i>BMC Pediatrics</i>, http://hdl.handle.net/11427/28307 en_ZA
dc.identifier.chicagocitation Chingono, R, H Mebrahtu, Z Mupambireyi, V Simms, H A Weiss, P Ndlovu, F Charasika, et al "Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial." <i>BMC Pediatrics</i> (2018) http://hdl.handle.net/11427/28307 en_ZA
dc.identifier.vancouvercitation Chingono R, Mebrahtu H, Mupambireyi Z, Simms V, Weiss HA, Ndlovu P, et al. Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial. BMC Pediatrics. 2018; http://hdl.handle.net/11427/28307. en_ZA
dc.identifier.ris TY - Journal Article AU - Chingono, R AU - Mebrahtu, H AU - Mupambireyi, Z AU - Simms, V AU - Weiss, H A AU - Ndlovu, P AU - Charasika, F AU - Tomlinson, M AU - Cluver, L D AU - Cowan, F M AU - Sherr, L AB - Background HIV infection in a family may affect optimum child development. Our hypothesis is that child development outcomes among HIV-exposed infants will be improved through a complex early childhood stimulation (ECS) programme, and income and loans saving programme for HIV positive parents. Methods The study was a cluster-randomized controlled trial in 30 clinic sites in two districts in Zimbabwe. Clinics were randomised in a 1:1 allocation ratio to the Child Health Intervention for Development Outcomes (CHIDO) intervention or Ministry of Health standard care. The CHIDO intervention comprises three elements: a group ECS parenting programme, an internal savings and lending scheme (ISALS) and case-management home visits by village health workers. The intervention was aimed at caregiver-child dyads (child aged 0–24 months) where the infant was HIV exposed or infected. The primary outcomes were cognitive development (assessed by the Mullen Scales of Early Learning) and retention of the child in HIV care, at 12 months after enrolment. A comprehensive process evaluation was conducted. Discussion The results of this cluster-randomised trial will provide important information regarding the effects of multi-component interventions in mitigating developmental delays in HIV-exposed infants living in resource-limited environments. Trial registration This trial is registered with the Pan African Clinical Trials Registry ( www.pactr.org ), registration number PACTR201701001387209; the trial was registered on 16th January 2017 (retrospectively registered). DA - 2018-07-09 DB - OpenUCT DP - University of Cape Town J1 - BMC Pediatrics LK - https://open.uct.ac.za PB - University of Cape Town PY - 2018 T1 - Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial TI - Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial UR - http://hdl.handle.net/11427/28307 ER - en_ZA


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