Dilatation in the femoral vascular bed does not cause retrograde relaxation of the iliac artery in the anaesthetized pig

 

Show simple item record

dc.contributor.author Markos, F
dc.contributor.author Ruane‐O’Hora, T
dc.contributor.author Snow, H M
dc.contributor.author Kelly, R
dc.contributor.author Wainwright, C
dc.contributor.author Skene, K
dc.contributor.author Drake-Holland, A J
dc.contributor.author Noble, M I M
dc.date.accessioned 2018-06-06T08:40:16Z
dc.date.available 2018-06-06T08:40:16Z
dc.date.issued 2008
dc.identifier http://dx.doi.org/10.1111/j.1748-1716.2008.01882.x
dc.identifier.citation Markos, F., Ruane‐O’Hora, T., Snow, H. M., Kelly, R., Wainwright, C., Skene, K., ... & Noble, M. I. M. (2008). Dilatation in the femoral vascular bed does not cause retrograde relaxation of the iliac artery in the anaesthetized pig. Acta physiologica, 194(3), 207-213.
dc.identifier.uri http://hdl.handle.net/11427/28231
dc.description.abstract Aim:  We tested the hypothesis that dilatation of a feeding artery may be elicited by transmission of a signal through the tissue of the arterial wall from a vasodilated peripheral vascular bed. Methods:  In eight pentobarbital anaesthetized pigs, acetylcholine (ACh, an endothelium-dependent vasodilator) was injected intra-arterially above (upstream) and below (downstream) a test segment of the left iliac artery, the diameter of which was measured continuously by sonomicrometry. Results:  Under control conditions, ACh injections upstream and downstream of the test segment caused dilatation. Downstream injection dilated the peripheral arterioles, resulting in increased blood flow and proximal dilatation. This is a shear stress, nitric oxide (NO)-dependent response. The experiment was then repeated after applying a stenosis to prevent the increased flow caused by downstream injection of ACh; the stenosis was placed either above the site of diameter measurement to allow retrograde conduction, or below that site to prevent distally injected ACh reaching the measurement site. Under these conditions, downstream injection of ACh had a minimal effect on the shear stress of the test segment with no increase in test segment diameter. This was not due to endothelial damage or dysfunction as injection of ACh upstream still caused a large increase in test segment diameter. Conclusions:  Our results indicate that dilatation of the feeding artery of a vasodilated bed is caused by increased shear stress within the feeding artery and not via a signal transmitted through the arterial wall from below.
dc.source Acta Physiologica
dc.source.uri https://onlinelibrary.wiley.com/journal/17481716
dc.subject.other endothelium
dc.subject.other endothelium-dependent hyperpolarizing factor
dc.subject.other nitric oxide
dc.subject.other shear stress
dc.title Dilatation in the femoral vascular bed does not cause retrograde relaxation of the iliac artery in the anaesthetized pig
dc.date.updated 2016-01-20T10:04:18Z
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Cardiothoracic Surgery en_ZA
uct.type.filetype Text
uct.type.filetype Image


Files in this item

This item appears in the following Collection(s)

Show simple item record