The biological properties of three trichothecene mycotoxins produces by fusaris

 

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dc.contributor.advisor Thiel, Pieter G en_ZA
dc.contributor.advisor Ivanetich, Kathryn M en_ZA
dc.contributor.author Janse Van Rensburg, Daniel Francois en_ZA
dc.date.accessioned 2018-02-01T13:32:52Z
dc.date.available 2018-02-01T13:32:52Z
dc.date.issued 1986 en_ZA
dc.identifier.citation Janse Van Rensburg, D. 1986. The biological properties of three trichothecene mycotoxins produces by fusaris. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/27209
dc.description.abstract The highly toxic fungal metabolite, neosolaniol monoacetate, was isolated and purified from cultures of Fusarium sambucinum. Since little is known about its toxic properties, the biological effects of this trichothecene were compared to those caused by diacetoxy-scirpenol in male Wistar rats. The lesions caused by the two toxins were very similar. Chronic exposure to either toxin led to a significant decrease (P<0.05) in red blood cell counts and a significant increase (P<0.05) in platelet size. The major pathological lesions observed were atrophy of the actively dividing cells of the bone marrow, thymus, spleen and lymph nodes. The reported species difference in T-2 toxin toxicity was investigated by determining the deacylation rate of T-2 toxin to HT-2 toxin, one of the first steps in the detoxification of this trichothecene. The high deacylation rate catalysed by rat microsomes correlated with the low sensitivity of this species to T-2 toxin, whereas the low deacylation rates with cat and monkey microsomes agreed with their high sensitivity. In contrast to this, the apparently high toxicity of T-2 toxin to humans does not correlate with the high deacylation rate observed in human hepatic microsomes. Involvement of the UDP-glucuronyltransferases in the detoxification of T-2 toxin was studied with rat and pig hepatic microsomes. T-2 toxin and two of its metabolites, HT-2 toxin and T-2 tetraol, did not appear to act as substrates for these enzymes under the in vitro conditions used. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Mycotoxins en_ZA
dc.subject.other Sesquiterpenes en_ZA
dc.subject.other Fusarium en_ZA
dc.title The biological properties of three trichothecene mycotoxins produces by fusaris en_ZA
dc.type Thesis / Dissertation en_ZA
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Medical Biochemistry & Structural Biology en_ZA
dc.type.qualificationlevel Masters en_ZA
dc.type.qualificationname MSc (Med) en_ZA
uct.type.filetype Text
uct.type.filetype Image


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