The investigation of the calcium antagonist nifedipine on fetal umbilical artery Doppler waveforms

 

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dc.contributor.advisor Lindow, Stephen en_ZA
dc.contributor.author Puzey, Martin Stanley en_ZA
dc.date.accessioned 2018-01-30T13:59:51Z
dc.date.available 2018-01-30T13:59:51Z
dc.date.issued 1992 en_ZA
dc.identifier.citation Puzey, M. 1992. The investigation of the calcium antagonist nifedipine on fetal umbilical artery Doppler waveforms. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/27134
dc.description.abstract The following thesis will describe the investigation of the effect of nifedipine (a calcium antagonist) on the Doppler flow velocity waveform of the umbilical artery. The thesis is divided into two parts. The first section is a literature review of the three main aspects of the thesis namely: 1. The uteroplacental circulation in humans and the pathophysiology related to this circulation in hypertension and intrauterine growth retardation (IUGR). 2. The biokinetics of nifedipine and a review of the experiments that have been performed using the drug in human and animal models. 3. The principles of Doppler ultrasound and the literature pertaining to its use in the study of the uteroplacental circulation. The second part of the thesis is devoted to the effect of nifedipine on fetal umbilical artery Doppler waveform analysis. In the first ·stage of the investigation the effect of the drug on hypertensive mothers has been examined, and in the second stage the effect on fetuses that have an increased resistance index of the umbilical artery Doppler waveform. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Obstetrics and Gynaecology en_ZA
dc.subject.other Ultrasonic imaging en_ZA
dc.subject.other Nifedipine - pharmacology en_ZA
dc.subject.other Umbilical Arteries - drug effects en_ZA
dc.subject.other Ultrasonography, Prenatal en_ZA
dc.title The investigation of the calcium antagonist nifedipine on fetal umbilical artery Doppler waveforms en_ZA
dc.type Thesis / Dissertation en_ZA
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Obstetrics and Gynaecology en_ZA
dc.type.qualificationlevel Masters en_ZA
dc.type.qualificationname MMed en_ZA
uct.type.filetype Text
uct.type.filetype Image


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