Phenotypic and functional characterisation of cervical and peripheral HIV-1 specific T cell responses

Master Thesis

2007

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http://hdl.handle.net/11427/2712
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thesis_hsf_2007_liebenberg_lj.pdf (6.97 MB)
Authors
Liebenberg, Lenine Julie
Supervisors
Passmore, Jo-Ann
Burgers, Wendy
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University of Cape Town

Department
Division of Medical Microbiology
Faculty
Faculty of Health Sciences
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Abstract
Distinct HIV variants occur at the genital mucosa compared to in blood, which may similarly result in differences in HIV T cell responses. There have been no studies of the maturational status of HIV-specific T cells present at the female genital mucosa. This study aimed to characterise HIV-specific cervical immune responses and to determine if compartmentalized immune responses occur in chronic HIV infection by comparing the characteristics of T cells at the cervical mucosa to those in blood.
Description

Includes bibliographical references (leaves 92-109).

Reference:

Liebenberg, L. 2007. Phenotypic and functional characterisation of cervical and peripheral HIV-1 specific T cell responses. University of Cape Town.

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