Presisposing and protective HLA-DR and DQ alleles for rheumatoid arthritis in South African mixed-ancestry and Xhosa populations

 

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dc.contributor.author Rousseau, J
dc.contributor.author Pokorny, L
dc.contributor.author Glaser, J
dc.contributor.author Creemers, P C
dc.date.accessioned 2018-01-24T09:36:32Z
dc.date.available 2018-01-24T09:36:32Z
dc.date.issued 2003
dc.identifier.citation Rousseau, J., Pokorny, L., Glaser, J., & Creemers, P. C. (2003). Predisposing and protective HLA-DR and-DQ alleles for rheumatoid arthritis in South African mixed-ancestry and Xhosa populations: research letter. South African journal of science, 99(1 & 2), p-89.
dc.identifier.uri http://hdl.handle.net/11427/26911
dc.description.abstract We have investigated the distribution of the HLA-DRB1, -DQA1 and -DQB1 alleles in rheumatoid arthritis (RA) by comparing the allele frequencies in blood from 65 Cape coloured (mixed-ancestry) RA patients and 114 controls, and from 25 Xhosa RA patients and 94 controls. The strongest positive association with RA was found for the DRB10401 allele, followed by the DQA10301 and DQB10302 alleles, which are strongly linked with DRB10401. Data for both populations were statistically significant. In addition, DQB10501, which is in linkage disequilibrium with DR1 and DR10, showed a positive association with RA. These findings are in agreement with those for Caucasoids; they indicate that haplotypes that predispose for RA are highly conserved during evolution. Negative associations, that is, a protective effect for RA, were also found, but only for broad specificities; the associations were generally weaker. New findings were negative associations for DRB103, DRB10701, DQA10501 and DQB106. The DRB10301 and DQA10501 alleles are in linkage disequilibrium; a negative association was found in both populations. The negative association of DRB10701 was found only in the mixed-ancestry population and was absent in Xhosa. The effect of DQA106 was significant in both populations. Thus, the protective HLA-DR and DQ alleles show a greater ethnic diversity.
dc.source South African Journal of Science
dc.source.uri https://www.sajs.co.za/
dc.subject.other Rheumatoid arthritis
dc.subject.other HLA histocompatibility antigens
dc.subject.other South Africans
dc.title Presisposing and protective HLA-DR and DQ alleles for rheumatoid arthritis in South African mixed-ancestry and Xhosa populations
dc.type Journal Article
dc.date.updated 2016-01-13T10:04:04Z
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Clinical Laboratory Sciences en_ZA
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