Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide

 

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dc.contributor.advisor Vinik, A I en_ZA
dc.contributor.author Sive, Alan Avrom en_ZA
dc.date.accessioned 2017-12-11T10:15:53Z
dc.date.available 2017-12-11T10:15:53Z
dc.date.issued 1982 en_ZA
dc.identifier.citation Sive, A. 1982. Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/26525
dc.description.abstract Pancreatic polypeptide (PP) is a 36 amino-acid residue peptide which has recently been recognised in pancreatic endocrine cells. Although PP has a number of effects on gastrointestinal and pancreatic exocrine function, its physiological function has not been clarified. Studies were undertaken to elucidate four aspects of the physiology and pathophysiology of this candidate hormone. Firstly, factors affecting the release of human PP (hPP) were assessed in healthy subjects; secondly polyacrylamide gel electrophoresis was used to investigate molecular heterogeneity of the peptide; thirdly, the organ uptake and half-life time of endogenous PP was measured in pigs; and finally, basal and stimulated serum hPP concentrations were assayed in patients with acute pancreatitis, chronic pancreatitis and maturity-onset diabetes mellitus. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Diabetology en_ZA
dc.title Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide en_ZA
dc.type Doctoral Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Endocrinology and Diabetology en_ZA
dc.type.qualificationlevel Doctoral
dc.type.qualificationname MD en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Sive, A. A. (1982). <i>Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Endocrinology and Diabetology. Retrieved from http://hdl.handle.net/11427/26525 en_ZA
dc.identifier.chicagocitation Sive, Alan Avrom. <i>"Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Endocrinology and Diabetology, 1982. http://hdl.handle.net/11427/26525 en_ZA
dc.identifier.vancouvercitation Sive AA. Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Endocrinology and Diabetology, 1982 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/26525 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Sive, Alan Avrom AB - Pancreatic polypeptide (PP) is a 36 amino-acid residue peptide which has recently been recognised in pancreatic endocrine cells. Although PP has a number of effects on gastrointestinal and pancreatic exocrine function, its physiological function has not been clarified. Studies were undertaken to elucidate four aspects of the physiology and pathophysiology of this candidate hormone. Firstly, factors affecting the release of human PP (hPP) were assessed in healthy subjects; secondly polyacrylamide gel electrophoresis was used to investigate molecular heterogeneity of the peptide; thirdly, the organ uptake and half-life time of endogenous PP was measured in pigs; and finally, basal and stimulated serum hPP concentrations were assayed in patients with acute pancreatitis, chronic pancreatitis and maturity-onset diabetes mellitus. DA - 1982 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1982 T1 - Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide TI - Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide UR - http://hdl.handle.net/11427/26525 ER - en_ZA


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