Altered bone metabolism in the protein deprived rat

 

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dc.contributor.advisor Pimstone, Bernard en_ZA
dc.contributor.author Le Roith, Derek en_ZA
dc.date.accessioned 2017-10-23T06:35:15Z
dc.date.available 2017-10-23T06:35:15Z
dc.date.issued 1973 en_ZA
dc.identifier.citation Le Roith, D. 1973. Altered bone metabolism in the protein deprived rat. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/25725
dc.description.abstract In contrast to the vast amount of active research and available knowledge on many aspects of protein-calorie malnutrition, surprisingly little attention has been focused on the skeletal effects of this syndrome. As early as the 1920's it was realised that the skeletal metabolism in protein-calorie malnutrition was deranged. Notwithstanding this, there is still to date inadequate understanding of the mechanisms by which these skeletal changes are brought about. This is partly due to the fact that the research workers were "victims of their times" in that the techniques utilised gave limited information and it has only been in the past decade or two that more sophisticated techniques have become available. (Evidence for this will be borne out in the following chapter where the literature is reviewed). It was with this in mind that the work presented in this thesis was undertaken. Part I of the thesis consists of a review of the literature, followed by a dissertation on the normal physiological concepts of calcium metabolism as well as a description of the calcium pools used in kinetic models. Part II includes all the chapters on the various experiments performed. Included in each chapter are the methods used, results obtained as well as a discourse relevant to that particular study, with special reference to similar experiments performed by other authors. Part III encompasses the integrated summary of the results and a discussion theorising the mechanisms involved in those changes. Finally, an appendix which deals with the statistical methods used for analyses, as well as details of those techniques which were used, but were established by other authors. en_ZA
dc.language.iso eng en_ZA
dc.subject.other bone metabolism en_ZA
dc.title Altered bone metabolism in the protein deprived rat en_ZA
dc.type Doctoral Thesis
dc.date.updated 2017-07-20T12:45:12Z
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Medicine en_ZA
dc.type.qualificationlevel Doctoral
dc.type.qualificationname PhD en_ZA
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uct.type.filetype Text
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dc.identifier.apacitation Le Roith, D. (1973). <i>Altered bone metabolism in the protein deprived rat</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/25725 en_ZA
dc.identifier.chicagocitation Le Roith, Derek. <i>"Altered bone metabolism in the protein deprived rat."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 1973. http://hdl.handle.net/11427/25725 en_ZA
dc.identifier.vancouvercitation Le Roith D. Altered bone metabolism in the protein deprived rat. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 1973 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/25725 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Le Roith, Derek AB - In contrast to the vast amount of active research and available knowledge on many aspects of protein-calorie malnutrition, surprisingly little attention has been focused on the skeletal effects of this syndrome. As early as the 1920's it was realised that the skeletal metabolism in protein-calorie malnutrition was deranged. Notwithstanding this, there is still to date inadequate understanding of the mechanisms by which these skeletal changes are brought about. This is partly due to the fact that the research workers were "victims of their times" in that the techniques utilised gave limited information and it has only been in the past decade or two that more sophisticated techniques have become available. (Evidence for this will be borne out in the following chapter where the literature is reviewed). It was with this in mind that the work presented in this thesis was undertaken. Part I of the thesis consists of a review of the literature, followed by a dissertation on the normal physiological concepts of calcium metabolism as well as a description of the calcium pools used in kinetic models. Part II includes all the chapters on the various experiments performed. Included in each chapter are the methods used, results obtained as well as a discourse relevant to that particular study, with special reference to similar experiments performed by other authors. Part III encompasses the integrated summary of the results and a discussion theorising the mechanisms involved in those changes. Finally, an appendix which deals with the statistical methods used for analyses, as well as details of those techniques which were used, but were established by other authors. DA - 1973 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1973 T1 - Altered bone metabolism in the protein deprived rat TI - Altered bone metabolism in the protein deprived rat UR - http://hdl.handle.net/11427/25725 ER - en_ZA


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