The HIV‑1 transmission bottleneck

 

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dc.contributor.author Kariuki, Samuel Mundia
dc.contributor.author Selhorst, Philippe
dc.contributor.author Ariën, Kevin K
dc.contributor.author Dorfman, Jeffrey Robert
dc.date.accessioned 2017-09-13T07:59:33Z
dc.date.available 2017-09-13T07:59:33Z
dc.date.issued 2017-03-25
dc.identifier.citation Kariuki, S. M., Selhorst, P., Ariën, K. K., & Dorfman, J. R. (2017). The HIV-1 transmission bottleneck. Retrovirology, 14(1), 22. DOI: 10.1186/s12977-017-0343-8 en_ZA
dc.identifier.uri http://hdl.handle.net/11427/25148
dc.description.abstract It is well established that most new systemic infections of HIV-1 can be traced back to one or a limited number of founder viruses. Usually, these founders are more closely related to minor HIV-1 populations in the blood of the presumed donor than to more abundant lineages. This has led to the widely accepted idea that transmission selects for viral characteristics that facilitate crossing the mucosal barrier of the recipient’s genital tract, although the specific selective forces or advantages are not completely defined. However, there are other steps along the way to becoming a founder virus at which selection may occur. These steps include the transition from the donor’s general circulation to the genital tract compartment, survival within the transmission fluid, and establishment of a nascent stable local infection in the recipient’s genital tract. Finally, there is the possibility that important narrowing events may also occur during establishment of systemic infection. This is suggested by the surprising observation that the number of founder viruses detected after transmission in intravenous drug users is also limited. Although some of these steps may be heavily selective, others may result mostly in a stochastic narrowing of the available founder pool. Collectively, they shape the initial infection in each recipient. en_ZA
dc.language eng en_ZA
dc.publisher Biomed Central en_ZA
dc.rights Creative Commons Attribution 4.0 International (CC BY 4.0) *
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ en_ZA
dc.source Retrovirology en_ZA
dc.source.uri https://retrovirology.biomedcentral.com/
dc.subject.other HIV-1
dc.subject.other Transmission
dc.subject.other Bottleneck
dc.subject.other Genital mucosa
dc.subject.other Intravenous drug user
dc.title The HIV‑1 transmission bottleneck en_ZA
dc.type Journal Article en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
uct.subject.keywords HIV-1 Transmission Bottleneck en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Immunology en_ZA
uct.type.filetype Text
uct.type.filetype Image


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