The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease

 

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dc.contributor.advisor Allin, Rosemary
dc.contributor.advisor Folb, Peter I
dc.contributor.author Zent, Clive Steven
dc.contributor.author Zent, Clive Steven
dc.date.accessioned 2017-08-24T07:27:07Z
dc.date.available 2017-08-24T07:27:07Z
dc.date.issued 1991
dc.identifier.citation Zent, C., Zent, C. 1991. The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/24969
dc.description.abstract The use of aminoglycosides in the treatment of the febrile neutropaenic patient with haematological disease is difficult and often suboptimal. This study reviews the available literature to establish therapeutic guidelines in this population and then reports the use of a Bayesian statistics based predictive model to implement and manage therapy in 10 patients. A review of the literature on aminoglycoside Pharmacology and clinical use is essential to determine therapeutic guidelines for this population. Aminoglycosides are amino sugars in glycosidic linkage and are polycations at physiological PH. The antibiotic effect is mediated through inhibition of protein synthesis and disruption of cell membrane integrity. Principal use is in treatment of Gram negative infection although aminoglycosides have activity against some Gram positive organisms including staphylococci. Aminoglycosides are inactive against anaerobes. Acquired resistance is mediated by bacterial enzymatic drug metabolism. Aminoglycosides are nephro- and ototoxic, this is the major constraint in clinical use.
dc.language.iso eng
dc.language.iso eng
dc.subject.other Antibiotics, Aminoglycoside - pharmacology
dc.subject.other Antibiotics, Aminoglycoside - therapeutic use
dc.subject.other Hematologic Diseases - drug therapy
dc.subject.other Neutropenia - drug therapy
dc.subject.other Antibiotics, Aminoglycoside - pharmacology~Antibiotics, Aminoglycoside - therapeutic use~Hematologic Diseases - drug therapy~Neutropenia - drug therapy
dc.title The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease
dc.title The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease
dc.type Master Thesis
dc.date.updated 2017-07-10T12:44:34Z
uct.type.publication Research
uct.type.resource Thesis
dc.publisher.institution University of Cape Town
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Medicine en_ZA
dc.type.qualificationlevel Masters
dc.type.qualificationname MMed
uct.type.filetype
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Zent, C. S., & Zent, C. S. (1991). <i>The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/24969 en_ZA
dc.identifier.chicagocitation Zent, Clive Steven, and Clive Steven Zent. <i>"The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 1991. http://hdl.handle.net/11427/24969 en_ZA
dc.identifier.vancouvercitation Zent CS, Zent CS. The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 1991 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/24969 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Zent, Clive Steven AU - Zent, Clive Steven AB - The use of aminoglycosides in the treatment of the febrile neutropaenic patient with haematological disease is difficult and often suboptimal. This study reviews the available literature to establish therapeutic guidelines in this population and then reports the use of a Bayesian statistics based predictive model to implement and manage therapy in 10 patients. A review of the literature on aminoglycoside Pharmacology and clinical use is essential to determine therapeutic guidelines for this population. Aminoglycosides are amino sugars in glycosidic linkage and are polycations at physiological PH. The antibiotic effect is mediated through inhibition of protein synthesis and disruption of cell membrane integrity. Principal use is in treatment of Gram negative infection although aminoglycosides have activity against some Gram positive organisms including staphylococci. Aminoglycosides are inactive against anaerobes. Acquired resistance is mediated by bacterial enzymatic drug metabolism. Aminoglycosides are nephro- and ototoxic, this is the major constraint in clinical use. DA - 1991 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1991 T1 - The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease TI - The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease UR - http://hdl.handle.net/11427/24969 ER - en_ZA


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