Omics-based molecular techniques in oral pathology centred cancer: prospect and challenges in Africa
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2017-06-05
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Cancer Cell International
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BioMed Central
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University of Cape Town
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Abstract
Background: The completion of the human genome project and the accomplished milestones in the human proteome project; as well as the progress made so far in computational bioinformatics and “big data” processing have contributed immensely to individualized/personalized medicine in the developed world. Main body: At the dawn of precision medicine, various omics-based therapies and bioengineering can now be applied accurately for the diagnosis, prognosis, treatment, and risk stratifcation of cancer in a manner that was hitherto not thought possible. The widespread introduction of genomics and other omics-based approaches into the postgraduate training curriculum of diverse medical and dental specialties, including pathology has improved the profciency of practitioners in the use of novel molecular signatures in patient management. In addition, intricate details about disease disparity among diferent human populations are beginning to emerge. This would facilitate the use of tailor-made novel theranostic methods based on emerging molecular evidences. Conclusion: In this review, we examined the challenges and prospects of using currently available omics-based technologies vis-à-vis oral pathology as well as prompt cancer diagnosis and treatment in a resource limited setting.
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Reference:
Adeola, H. A., Soyele, O. O., Adefuye, A. O., Jimoh, S. A., & Butali, A. (2017). Omics-based molecular techniques in oral pathology centred cancer: prospect and challenges in Africa. Cancer Cell International, 17(1), 61.