The agreement between cervical abnormalities identified by cytology and detection of high-risk types of human papillomavirus

 

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dc.contributor.author Allan, Bruce R
dc.contributor.author Marais, Dianne J
dc.contributor.author Denny, Lynette
dc.contributor.author Hoffman, Margaret
dc.contributor.author Shapiro, Samuel
dc.contributor.author Williamson, Anna-Lise
dc.date.accessioned 2017-05-17T10:19:24Z
dc.date.available 2017-05-17T10:19:24Z
dc.date.issued 2006
dc.identifier http://dx.doi.org/10.7196/SAMJ.1344
dc.identifier.citation Allan, B., Marais, D., Denny, L., Hoffman, M., Shapiro, S., & Williamson, A. (2008). The agreement between cervical abnormalities identified by cytology and detection of high-risk types of human papillomavirus. South African Medical Journal, 96(11), 1186.
dc.identifier.uri http://hdl.handle.net/11427/24347
dc.description.abstract Objectives and design. Human papillomavirus (HPV) is causally associated with cervical cancer. Using the Digene Hybrid Capture 2 high-risk HPV test (HC2), we investigated the prevalence of high-risk HPV in cervical specimens, and compared results with those of Papanicolaou (Pap) smears taken concurrently Subjects and setting. Cervical specimens were obtained from women attending hospitals/community health centres in the Western Cape province of South Africa. They were participating in a case-control study of the association of hormonal contraceptives and invasive cervical cancer. Results. Of 1 491 women tested, 254 (17%) were HPV DNA positive. The age-specific prevalence of HPV was 36/97 (37.1%) in those aged < 30 years, 78/369 (21.1%) in those aged 30 - 39 years, 78/603 (12.9%) in those aged 40 - 49 years and 62/422 (14.7%) in those aged 50 - 59 years. In women with normal cytology the prevalence of HPV was 10.9% (138/1 264); in those with abnormal squamous cells of unknown significance (AS-CUS) it was 30.8% (36/117); in those with low-grade squamous intraepithelial lesions (LSIL) it was 63.2% (36/57), and in those with high-grade squamous intraepithelial lesions (HSIL) it was 83% (44/53). The odds ratio between HPV and HSIL in women aged 40 - 59 years was 57.1 (confidence interval 22.4 - 170.7). Conclusions. HC2 detected a high prevalence of HPV (17%) in this population. Most women with HSIL (83%) were positive, indicating that HPV testing of AS-CUS women may aid in management. When costs decrease, HC2 could be introduced as an adjunct to Pap smears in identifying women at risk for high-grade cervical disease and could be useful in the maintenance of cervical health in those who remain Pap smear negative.
dc.source South African Medical Journal
dc.source.uri http://www.samj.org.za/index.php/samj
dc.subject.other High-risk human papillomavirus
dc.subject.other Prevalence
dc.subject.other Cervical specimens
dc.subject.other Pap smears
dc.subject.other Cervical cancer
dc.title The agreement between cervical abnormalities identified by cytology and detection of high-risk types of human papillomavirus
dc.type Journal Article en_ZA
dc.date.updated 2016-01-08T08:28:13Z
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Institute of Infectious Disease and Molecular Medicine en_ZA
uct.type.filetype Text
uct.type.filetype Image


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