The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum

 

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dc.contributor.advisor Egan, Timothy J en_ZA
dc.contributor.advisor Smith, Peter en_ZA
dc.contributor.author Combrinck, Jill Michelle en_ZA
dc.date.accessioned 2017-01-17T12:23:31Z
dc.date.available 2017-01-17T12:23:31Z
dc.date.issued 2016 en_ZA
dc.identifier.citation Combrinck, J. 2016. The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/22760
dc.description.abstract The malaria parasite detoxifies host red blood cell derived haem by conversion into the inert biocrystal haemozoin. Inhibiting this critical pathway is proposed to be the mechanism of action of chloroquine and related antimalarials and several studies have linked inhibition of the formation of synthetic haemozoin, β-haematin, to parasite survival. However, haemozoin inhibition with a dose related increase in "free" haem correlated to decreased survival has not been demonstrated in the parasite. This project investigated the role of haem in the mechanism of action of several clinically relevant and novel antimalarials in the malaria parasite, Plasmodium falciparum. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Pharmacology en_ZA
dc.title The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum en_ZA
dc.type Doctoral Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Clinical Pharmacology en_ZA
dc.type.qualificationlevel Doctoral
dc.type.qualificationname PhD en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Combrinck, J. M. (2016). <i>The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology. Retrieved from http://hdl.handle.net/11427/22760 en_ZA
dc.identifier.chicagocitation Combrinck, Jill Michelle. <i>"The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 2016. http://hdl.handle.net/11427/22760 en_ZA
dc.identifier.vancouvercitation Combrinck JM. The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 2016 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/22760 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Combrinck, Jill Michelle AB - The malaria parasite detoxifies host red blood cell derived haem by conversion into the inert biocrystal haemozoin. Inhibiting this critical pathway is proposed to be the mechanism of action of chloroquine and related antimalarials and several studies have linked inhibition of the formation of synthetic haemozoin, β-haematin, to parasite survival. However, haemozoin inhibition with a dose related increase in "free" haem correlated to decreased survival has not been demonstrated in the parasite. This project investigated the role of haem in the mechanism of action of several clinically relevant and novel antimalarials in the malaria parasite, Plasmodium falciparum. DA - 2016 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum TI - The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum UR - http://hdl.handle.net/11427/22760 ER - en_ZA


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