Factors affecting the separation of organic compounds by gas liquid chromatography

 

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dc.contributor.advisor Leisegang, E C en_ZA
dc.contributor.advisor Stephen, A M en_ZA
dc.contributor.author Hagens, Rodger Graham Robertson en_ZA
dc.date.accessioned 2016-10-20T03:38:22Z
dc.date.available 2016-10-20T03:38:22Z
dc.date.issued 1965 en_ZA
dc.identifier.citation Hagens, R. 1965. Factors affecting the separation of organic compounds by gas liquid chromatography. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/22222
dc.description.abstract The objects of this thesis have been threefold. In the first place it has been an investigation of the factors which influence retention time in an attempt to predict the retentions of new compounds. Secondly it has been an investigation into the conditions for the best separation of diastereoisomers, and thirdly it has been an application of gas chromatography in the study of the forces of intermolecular interaction in solution. To carry out these investigations, the retention times of twenty five monofunctional and bifunctional compounds have been determined on four stationary liquids at 130°C. It was found that by dividing the retention time of a solute by that of a hypothetical normal hydrocarbon of the same molar volume of the solute, a functional group constant was obtained. By means of this constant, termed the Group Retention Factor, it was found that it is possible to predict the retention of bifunctional compounds. The separation of diastereoisomeric pairs is discussed in terms of the Group Retention Factors of the functional groups on the diastereomers. The molar volume is also utilized in order to develop an equation by means of which the ratio of retention times on two solvents can be related to the forces of interaction between solute and solvent. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Chemistry en_ZA
dc.title Factors affecting the separation of organic compounds by gas liquid chromatography en_ZA
dc.type Master Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Science en_ZA
dc.publisher.department Department of Chemistry en_ZA
dc.type.qualificationlevel Masters
dc.type.qualificationname MSc en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Hagens, R. G. R. (1965). <i>Factors affecting the separation of organic compounds by gas liquid chromatography</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/22222 en_ZA
dc.identifier.chicagocitation Hagens, Rodger Graham Robertson. <i>"Factors affecting the separation of organic compounds by gas liquid chromatography."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 1965. http://hdl.handle.net/11427/22222 en_ZA
dc.identifier.vancouvercitation Hagens RGR. Factors affecting the separation of organic compounds by gas liquid chromatography. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 1965 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/22222 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Hagens, Rodger Graham Robertson AB - The objects of this thesis have been threefold. In the first place it has been an investigation of the factors which influence retention time in an attempt to predict the retentions of new compounds. Secondly it has been an investigation into the conditions for the best separation of diastereoisomers, and thirdly it has been an application of gas chromatography in the study of the forces of intermolecular interaction in solution. To carry out these investigations, the retention times of twenty five monofunctional and bifunctional compounds have been determined on four stationary liquids at 130°C. It was found that by dividing the retention time of a solute by that of a hypothetical normal hydrocarbon of the same molar volume of the solute, a functional group constant was obtained. By means of this constant, termed the Group Retention Factor, it was found that it is possible to predict the retention of bifunctional compounds. The separation of diastereoisomeric pairs is discussed in terms of the Group Retention Factors of the functional groups on the diastereomers. The molar volume is also utilized in order to develop an equation by means of which the ratio of retention times on two solvents can be related to the forces of interaction between solute and solvent. DA - 1965 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1965 T1 - Factors affecting the separation of organic compounds by gas liquid chromatography TI - Factors affecting the separation of organic compounds by gas liquid chromatography UR - http://hdl.handle.net/11427/22222 ER - en_ZA


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