Background: Developmental stress has been hypothesised to interact with genetic predisposition to increase the risk of developing substance use disorders. Here we have investigated the effects of maternal separation-induced developmental stress using a behavioural proxy of methamphetamine preference in an animal model of attentiondeficit/hyperactivity disorder, the spontaneously hypertensive rat, versus Wistar Kyoto and Sprague–Dawley comparator strains. Results: Analysis of results obtained using a conditioned place preference paradigm revealed a significant strain × stress interaction with maternal separation inducing preference for the methamphetamine-associated compartment in spontaneously hypertensive rats. Maternal separation increased behavioural sensitization to the locomotor-stimulatory effects of methamphetamine in both spontaneously hypertensive and Sprague–Dawley strains but not in Wistar Kyoto rats. Conclusions: Our findings indicate that developmental stress in a genetic rat model of attention-deficit/hyperactivity disorder may foster a vulnerability to the development of substance use disorders.
Reference:
Womersley, J. S., Mpeta, B., Dimatelis, J. J., Kellaway, L. A., Stein, D. J., & Russell, V. A. (2016). Developmental stress elicits preference for methamphetamine in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder. Behavioral and Brain Functions, 12(1), 18.
Womersley, J. S., Mpeta, B., Dimatelis, J. J., Kellaway, L. A., Stein, D. J., & Russell, V. A. (2016). Developmental stress elicits preference for methamphetamine in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder. Behavioral and Brain Functions, http://hdl.handle.net/11427/21020
Womersley, Jacqueline S, Bafokeng Mpeta, Jacqueline J Dimatelis, Lauriston A Kellaway, Dan J Stein, and Vivienne A Russell "Developmental stress elicits preference for methamphetamine in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder." Behavioral and Brain Functions (2016) http://hdl.handle.net/11427/21020
Womersley JS, Mpeta B, Dimatelis JJ, Kellaway LA, Stein DJ, Russell VA. Developmental stress elicits preference for methamphetamine in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder. Behavioral and Brain Functions. 2016; http://hdl.handle.net/11427/21020.
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