Characterisation of mucosal tissue in the foreskin after voluntary medical male circumcision

 

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dc.contributor.advisor Gray, Clive M en_ZA
dc.contributor.advisor Olivier, Abraham Jacobus en_ZA
dc.contributor.author Harryparsad, Rushil en_ZA
dc.date.accessioned 2016-07-21T11:04:46Z
dc.date.available 2016-07-21T11:04:46Z
dc.date.issued 2016 en_ZA
dc.identifier.citation Harryparsad, R. 2016. Characterisation of mucosal tissue in the foreskin after voluntary medical male circumcision. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/20563
dc.description.abstract Background: Medical Male Circumcision (MMC) reduces the risk of HIV-1 acquisition by up to 60% as shown in a number of randomized controlled trials in Uganda, Kenya and South Africa. MMC has also been shown to reduce the prevalence of other sexually transmitted infections (STIs) like Herpes Simplex Virus (HSV) -2 and Human Papillomavirus (HPV) by 25% and 35% respectively. Asymptomatic STIs may elevate the risk of HIV-1 acquisition by recruiting HIV-1 target cells to the foreskin. The higher permeability of the inner foreskin may play a role in HIV-1 acquisition as well as the number of target cells present in the foreskin. The more inflamed inner foreskin may be increasing the risk of a productive HIV-1 infection. The aims of this dissertation was to a) examine the levels of keratinisation in the inner and outer foreskins after MMC; b) investigate the number of Langerhans, Ki67+ and CD4+ T cells in the inner and outer foreskin and c) identify the impact of asymptomatic STIs on the numbers and proliferative capacity of foreskin-resident Langerhans and CD4+ T cells. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Clinical Sciences and Immunology en_ZA
dc.title Characterisation of mucosal tissue in the foreskin after voluntary medical male circumcision en_ZA
dc.type Master Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Immunology en_ZA
dc.type.qualificationlevel Masters
dc.type.qualificationname MSc (Med) en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Harryparsad, R. (2016). <i>Characterisation of mucosal tissue in the foreskin after voluntary medical male circumcision</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Immunology. Retrieved from http://hdl.handle.net/11427/20563 en_ZA
dc.identifier.chicagocitation Harryparsad, Rushil. <i>"Characterisation of mucosal tissue in the foreskin after voluntary medical male circumcision."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Immunology, 2016. http://hdl.handle.net/11427/20563 en_ZA
dc.identifier.vancouvercitation Harryparsad R. Characterisation of mucosal tissue in the foreskin after voluntary medical male circumcision. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Immunology, 2016 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/20563 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Harryparsad, Rushil AB - Background: Medical Male Circumcision (MMC) reduces the risk of HIV-1 acquisition by up to 60% as shown in a number of randomized controlled trials in Uganda, Kenya and South Africa. MMC has also been shown to reduce the prevalence of other sexually transmitted infections (STIs) like Herpes Simplex Virus (HSV) -2 and Human Papillomavirus (HPV) by 25% and 35% respectively. Asymptomatic STIs may elevate the risk of HIV-1 acquisition by recruiting HIV-1 target cells to the foreskin. The higher permeability of the inner foreskin may play a role in HIV-1 acquisition as well as the number of target cells present in the foreskin. The more inflamed inner foreskin may be increasing the risk of a productive HIV-1 infection. The aims of this dissertation was to a) examine the levels of keratinisation in the inner and outer foreskins after MMC; b) investigate the number of Langerhans, Ki67+ and CD4+ T cells in the inner and outer foreskin and c) identify the impact of asymptomatic STIs on the numbers and proliferative capacity of foreskin-resident Langerhans and CD4+ T cells. DA - 2016 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - Characterisation of mucosal tissue in the foreskin after voluntary medical male circumcision TI - Characterisation of mucosal tissue in the foreskin after voluntary medical male circumcision UR - http://hdl.handle.net/11427/20563 ER - en_ZA


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