Computational biomechanics in the remodelling rat heart post myocardial infarction

 

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dc.contributor.advisor Franz , Thomas en_ZA
dc.contributor.advisor Davies, Neil en_ZA
dc.contributor.advisor Dubuis, Laura en_ZA
dc.contributor.author Masithulela, Fulufhelo James en_ZA
dc.date.accessioned 2016-07-21T11:01:14Z
dc.date.available 2016-07-21T11:01:14Z
dc.date.issued 2016 en_ZA
dc.identifier.citation Masithulela, F. 2016. Computational biomechanics in the remodelling rat heart post myocardial infarction. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/20555
dc.description.abstract Cardiovascular diseases account for one third of all deaths worldwide, more than 33% of which are related to ischemic heart disease, including myocardial infarction (MI). This thesis seeks to provide insight and understanding of mechanisms during different stages of MI by utilizing finite element (FE) modelling. Three-dimensional biventricular rat heart geometries were developed from cardiac magnetic resonance images of a healthy heart and a heart with left ventricular (LV) infarction two weeks and four weeks after infarct induction. From these geometries, FE models were established. To represent the myocardium, a structure-based constitutive model and a rule-based myofibre distribution were developed to simulate both passive mechanics and active contraction. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Cardiovascular Biomechanics en_ZA
dc.title Computational biomechanics in the remodelling rat heart post myocardial infarction en_ZA
dc.type Thesis / Dissertation en_ZA
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Cardiology en_ZA
dc.type.qualificationlevel Doctoral en_ZA
dc.type.qualificationname PhD en_ZA
uct.type.filetype Text
uct.type.filetype Image


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