Computational biomechanics in the remodelling rat heart post myocardial infarction

Masithulela, Fulufhelo James

dc.contributor.advisor	Franz , Thomas	en_ZA
dc.contributor.advisor	Davies, Neil	en_ZA
dc.contributor.advisor	Dubuis, Laura	en_ZA
dc.contributor.author	Masithulela, Fulufhelo James	en_ZA
dc.date.accessioned	2016-07-21T11:01:14Z
dc.date.available	2016-07-21T11:01:14Z
dc.date.issued	2016	en_ZA
dc.identifier.citation	Masithulela, F. 2016. Computational biomechanics in the remodelling rat heart post myocardial infarction. University of Cape Town.	en_ZA
dc.identifier.uri	http://hdl.handle.net/11427/20555
dc.description.abstract	Cardiovascular diseases account for one third of all deaths worldwide, more than 33% of which are related to ischemic heart disease, including myocardial infarction (MI). This thesis seeks to provide insight and understanding of mechanisms during different stages of MI by utilizing finite element (FE) modelling. Three-dimensional biventricular rat heart geometries were developed from cardiac magnetic resonance images of a healthy heart and a heart with left ventricular (LV) infarction two weeks and four weeks after infarct induction. From these geometries, FE models were established. To represent the myocardium, a structure-based constitutive model and a rule-based myofibre distribution were developed to simulate both passive mechanics and active contraction.	en_ZA
dc.language.iso	eng	en_ZA
dc.subject.other	Cardiovascular Biomechanics	en_ZA
dc.title	Computational biomechanics in the remodelling rat heart post myocardial infarction	en_ZA
dc.type	Doctoral Thesis
uct.type.publication	Research	en_ZA
uct.type.resource	Thesis	en_ZA
dc.publisher.institution	University of Cape Town
dc.publisher.faculty	Faculty of Health Sciences	en_ZA
dc.publisher.department	Division of Cardiology	en_ZA
dc.type.qualificationlevel	Doctoral
dc.type.qualificationname	PhD	en_ZA
uct.type.filetype	Text
uct.type.filetype	Image
dc.identifier.apacitation	Masithulela, F. J. (2016). <i>Computational biomechanics in the remodelling rat heart post myocardial infarction</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Cardiology. Retrieved from http://hdl.handle.net/11427/20555	en_ZA
dc.identifier.chicagocitation	Masithulela, Fulufhelo James. <i>"Computational biomechanics in the remodelling rat heart post myocardial infarction."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Cardiology, 2016. http://hdl.handle.net/11427/20555	en_ZA
dc.identifier.vancouvercitation	Masithulela FJ. Computational biomechanics in the remodelling rat heart post myocardial infarction. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Cardiology, 2016 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/20555	en_ZA
dc.identifier.ris	TY - Thesis / Dissertation AU - Masithulela, Fulufhelo James AB - Cardiovascular diseases account for one third of all deaths worldwide, more than 33% of which are related to ischemic heart disease, including myocardial infarction (MI). This thesis seeks to provide insight and understanding of mechanisms during different stages of MI by utilizing finite element (FE) modelling. Three-dimensional biventricular rat heart geometries were developed from cardiac magnetic resonance images of a healthy heart and a heart with left ventricular (LV) infarction two weeks and four weeks after infarct induction. From these geometries, FE models were established. To represent the myocardium, a structure-based constitutive model and a rule-based myofibre distribution were developed to simulate both passive mechanics and active contraction. DA - 2016 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - Computational biomechanics in the remodelling rat heart post myocardial infarction TI - Computational biomechanics in the remodelling rat heart post myocardial infarction UR - http://hdl.handle.net/11427/20555 ER -	en_ZA