In vivo molecular dissection of the effects of HIV-1 in active tuberculosis

 

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dc.contributor.author Bell, Lucy C K en_ZA
dc.contributor.author Pollara, Gabriele en_ZA
dc.contributor.author Pascoe, Mellissa en_ZA
dc.contributor.author Tomlinson, Gillian S en_ZA
dc.contributor.author Lehloenya, Rannakoe J en_ZA
dc.contributor.author Roe, Jennifer en_ZA
dc.contributor.author Meldau, Richard en_ZA
dc.contributor.author Miller, Robert F en_ZA
dc.contributor.author Ramsay, Alan en_ZA
dc.contributor.author Chain, Benjamin M en_ZA
dc.contributor.author Dheda, Keertan en_ZA
dc.contributor.author Noursadeghi, Mahdad en_ZA
dc.date.accessioned 2016-04-13T12:35:47Z
dc.date.available 2016-04-13T12:35:47Z
dc.date.issued 2016 en_ZA
dc.identifier.citation Bell, L. C., Pollara, G., Pascoe, M., Tomlinson, G. S., Lehloenya, R. J., Roe, J., ... & Dheda, K. (2016). In vivo molecular dissection of the effects of HIV-1 in active tuberculosis. PLoS Pathog, 12(3), e1005469. doi:10.1371/journal.ppat.1005469 en_ZA
dc.identifier.uri http://dx.doi.org/10.1371/journal.ppat.1005469 en_ZA
dc.identifier.uri http://hdl.handle.net/11427/18853
dc.description.abstract Author Summary HIV-1 infected people have substantially increased risk of tuberculosis (TB) leading to a large burden of disease worldwide. We aimed to investigate how HIV-1 causes this effect by altering human immune responses. We measured the products of all immune genes at injection sites of sterilized TB under the skin, in order to look for differences between TB patients with and without HIV-1. We found that the predominant effect of early HIV-1 infection was to diminish a component of immune responses that contributes to prevention of harmful inflammation. In more advanced HIV-1, we found almost complete absence of any immune response to TB except for immune activity which is normally part of our defence against viruses, but may also weaken immune protection against TB. In some patients, TB becomes apparent after starting treatment for HIV-1. In these patients we found that most immune responses had recovered to normal levels, but that one type of response sometimes associated with asthma and allergies was exaggerated. Our findings provide new insights into how HIV-1 can affect immune responses and changes to the immune system that are associated with risk of TB, which will inform the development of new strategies to improve protective immunity. en_ZA
dc.language.iso eng en_ZA
dc.publisher Public Library of Science en_ZA
dc.rights This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source PLoS One en_ZA
dc.source.uri http://journals.plos.org/plospathogens en_ZA
dc.subject.other Tuberculosis en_ZA
dc.subject.other HIV-1 en_ZA
dc.subject.other Immune response en_ZA
dc.subject.other Mycobacterium tuberculosis en_ZA
dc.subject.other Transcriptome analysis en_ZA
dc.subject.other Gene expression en_ZA
dc.subject.other Blood en_ZA
dc.subject.other Inflammation en_ZA
dc.title In vivo molecular dissection of the effects of HIV-1 in active tuberculosis en_ZA
dc.type Journal Article en_ZA
dc.rights.holder © 2016 Bell et al en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Pulmonology en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Bell, L. C. K., Pollara, G., Pascoe, M., Tomlinson, G. S., Lehloenya, R. J., Roe, J., ... Noursadeghi, M. (2016). In vivo molecular dissection of the effects of HIV-1 in active tuberculosis. <i>PLoS One</i>, http://hdl.handle.net/11427/18853 en_ZA
dc.identifier.chicagocitation Bell, Lucy C K, Gabriele Pollara, Mellissa Pascoe, Gillian S Tomlinson, Rannakoe J Lehloenya, Jennifer Roe, Richard Meldau, et al "In vivo molecular dissection of the effects of HIV-1 in active tuberculosis." <i>PLoS One</i> (2016) http://hdl.handle.net/11427/18853 en_ZA
dc.identifier.vancouvercitation Bell LCK, Pollara G, Pascoe M, Tomlinson GS, Lehloenya RJ, Roe J, et al. In vivo molecular dissection of the effects of HIV-1 in active tuberculosis. PLoS One. 2016; http://hdl.handle.net/11427/18853. en_ZA
dc.identifier.ris TY - Journal Article AU - Bell, Lucy C K AU - Pollara, Gabriele AU - Pascoe, Mellissa AU - Tomlinson, Gillian S AU - Lehloenya, Rannakoe J AU - Roe, Jennifer AU - Meldau, Richard AU - Miller, Robert F AU - Ramsay, Alan AU - Chain, Benjamin M AU - Dheda, Keertan AU - Noursadeghi, Mahdad AB - Author Summary HIV-1 infected people have substantially increased risk of tuberculosis (TB) leading to a large burden of disease worldwide. We aimed to investigate how HIV-1 causes this effect by altering human immune responses. We measured the products of all immune genes at injection sites of sterilized TB under the skin, in order to look for differences between TB patients with and without HIV-1. We found that the predominant effect of early HIV-1 infection was to diminish a component of immune responses that contributes to prevention of harmful inflammation. In more advanced HIV-1, we found almost complete absence of any immune response to TB except for immune activity which is normally part of our defence against viruses, but may also weaken immune protection against TB. In some patients, TB becomes apparent after starting treatment for HIV-1. In these patients we found that most immune responses had recovered to normal levels, but that one type of response sometimes associated with asthma and allergies was exaggerated. Our findings provide new insights into how HIV-1 can affect immune responses and changes to the immune system that are associated with risk of TB, which will inform the development of new strategies to improve protective immunity. DA - 2016 DB - OpenUCT DO - 10.1371/journal.ppat.1005469 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - In vivo molecular dissection of the effects of HIV-1 in active tuberculosis TI - In vivo molecular dissection of the effects of HIV-1 in active tuberculosis UR - http://hdl.handle.net/11427/18853 ER - en_ZA


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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.