Preparation and solid state properties of cyclodextrin complexes of selected drug molecules

 

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dc.contributor.advisor Caira, Mino R en_ZA
dc.contributor.author Mvula, Eino Natangwe en_ZA
dc.date.accessioned 2016-03-17T07:18:50Z
dc.date.available 2016-03-17T07:18:50Z
dc.date.issued 1999 en_ZA
dc.identifier.citation Mvula, E. 1999. Preparation and solid state properties of cyclodextrin complexes of selected drug molecules. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/17902
dc.description Includes bibliographical references. en_ZA
dc.description.abstract A large number of pharmaceutically important drugs are poorly soluble in water. This study focuses on the 'smart' molecule that can enhance the solubility and hence increase the bioavailability of these drugs. This molecule is a cyclodextrin and is known to form inclusion compounds with various drug molecules. The preparation of β-cyclodextrin CP-CD), y-cyclodextrin (y-CD), heptakis(2,6-di-OJ, methyl)-β-cyclodextrin (Dimeb) and heptakis(2,3,6·tri-0-methyl)- β-cyclodextrin (Trimeb) 3, complexes with clofibric acid as well as the heptakis(2,3,6j·tri-O-methyl)- β-cyclodextrin (Trimeb) complex with clofibrate is reported. The complexes were characterised by thermogravimetric analysis (TG), differential scanning calorimetry (DSC), ultraviolet spectrophotometry (UV), infrared spectroscopy (IR), X-ray powder diffraction (XRD) and single crystal X-ray analysis. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Chemistry en_ZA
dc.title Preparation and solid state properties of cyclodextrin complexes of selected drug molecules en_ZA
dc.type Master Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Science en_ZA
dc.publisher.department Department of Chemistry en_ZA
dc.type.qualificationlevel Masters
dc.type.qualificationname MSc en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Mvula, E. N. (1999). <i>Preparation and solid state properties of cyclodextrin complexes of selected drug molecules</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/17902 en_ZA
dc.identifier.chicagocitation Mvula, Eino Natangwe. <i>"Preparation and solid state properties of cyclodextrin complexes of selected drug molecules."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 1999. http://hdl.handle.net/11427/17902 en_ZA
dc.identifier.vancouvercitation Mvula EN. Preparation and solid state properties of cyclodextrin complexes of selected drug molecules. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 1999 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/17902 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Mvula, Eino Natangwe AB - A large number of pharmaceutically important drugs are poorly soluble in water. This study focuses on the 'smart' molecule that can enhance the solubility and hence increase the bioavailability of these drugs. This molecule is a cyclodextrin and is known to form inclusion compounds with various drug molecules. The preparation of β-cyclodextrin CP-CD), y-cyclodextrin (y-CD), heptakis(2,6-di-OJ, methyl)-β-cyclodextrin (Dimeb) and heptakis(2,3,6·tri-0-methyl)- β-cyclodextrin (Trimeb) 3, complexes with clofibric acid as well as the heptakis(2,3,6j·tri-O-methyl)- β-cyclodextrin (Trimeb) complex with clofibrate is reported. The complexes were characterised by thermogravimetric analysis (TG), differential scanning calorimetry (DSC), ultraviolet spectrophotometry (UV), infrared spectroscopy (IR), X-ray powder diffraction (XRD) and single crystal X-ray analysis. DA - 1999 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1999 T1 - Preparation and solid state properties of cyclodextrin complexes of selected drug molecules TI - Preparation and solid state properties of cyclodextrin complexes of selected drug molecules UR - http://hdl.handle.net/11427/17902 ER - en_ZA


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