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| dc.contributor.advisor | Caira, Mino R | en_ZA |
| dc.contributor.author |
Mvula, Eino Natangwe
|
en_ZA |
| dc.date.accessioned | 2016-03-17T07:18:50Z | |
| dc.date.available | 2016-03-17T07:18:50Z | |
| dc.date.issued | 1999 | en_ZA |
| dc.identifier.citation | Mvula, E. 1999. Preparation and solid state properties of cyclodextrin complexes of selected drug molecules. University of Cape Town. | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/17902 | |
| dc.description | Includes bibliographical references. | en_ZA |
| dc.description.abstract | A large number of pharmaceutically important drugs are poorly soluble in water. This study focuses on the 'smart' molecule that can enhance the solubility and hence increase the bioavailability of these drugs. This molecule is a cyclodextrin and is known to form inclusion compounds with various drug molecules. The preparation of β-cyclodextrin CP-CD), y-cyclodextrin (y-CD), heptakis(2,6-di-OJ, methyl)-β-cyclodextrin (Dimeb) and heptakis(2,3,6·tri-0-methyl)- β-cyclodextrin (Trimeb) 3, complexes with clofibric acid as well as the heptakis(2,3,6j·tri-O-methyl)- β-cyclodextrin (Trimeb) complex with clofibrate is reported. The complexes were characterised by thermogravimetric analysis (TG), differential scanning calorimetry (DSC), ultraviolet spectrophotometry (UV), infrared spectroscopy (IR), X-ray powder diffraction (XRD) and single crystal X-ray analysis. | en_ZA |
| dc.language.iso | eng | en_ZA |
| dc.subject.other | Chemistry | en_ZA |
| dc.title | Preparation and solid state properties of cyclodextrin complexes of selected drug molecules | en_ZA |
| dc.type | Master Thesis | |
| uct.type.publication | Research | en_ZA |
| uct.type.resource | Thesis | en_ZA |
| dc.publisher.institution | University of Cape Town | |
| dc.publisher.faculty | Faculty of Science | en_ZA |
| dc.publisher.department | Department of Chemistry | en_ZA |
| dc.type.qualificationlevel | Masters | |
| dc.type.qualificationname | MSc | en_ZA |
| uct.type.filetype | Text | |
| uct.type.filetype | Image | |
| dc.identifier.apacitation | Mvula, E. N. (1999). <i>Preparation and solid state properties of cyclodextrin complexes of selected drug molecules</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/17902 | en_ZA |
| dc.identifier.chicagocitation | Mvula, Eino Natangwe. <i>"Preparation and solid state properties of cyclodextrin complexes of selected drug molecules."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 1999. http://hdl.handle.net/11427/17902 | en_ZA |
| dc.identifier.vancouvercitation | Mvula EN. Preparation and solid state properties of cyclodextrin complexes of selected drug molecules. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 1999 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/17902 | en_ZA |
| dc.identifier.ris | TY - Thesis / Dissertation AU - Mvula, Eino Natangwe AB - A large number of pharmaceutically important drugs are poorly soluble in water. This study focuses on the 'smart' molecule that can enhance the solubility and hence increase the bioavailability of these drugs. This molecule is a cyclodextrin and is known to form inclusion compounds with various drug molecules. The preparation of β-cyclodextrin CP-CD), y-cyclodextrin (y-CD), heptakis(2,6-di-OJ, methyl)-β-cyclodextrin (Dimeb) and heptakis(2,3,6·tri-0-methyl)- β-cyclodextrin (Trimeb) 3, complexes with clofibric acid as well as the heptakis(2,3,6j·tri-O-methyl)- β-cyclodextrin (Trimeb) complex with clofibrate is reported. The complexes were characterised by thermogravimetric analysis (TG), differential scanning calorimetry (DSC), ultraviolet spectrophotometry (UV), infrared spectroscopy (IR), X-ray powder diffraction (XRD) and single crystal X-ray analysis. DA - 1999 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1999 T1 - Preparation and solid state properties of cyclodextrin complexes of selected drug molecules TI - Preparation and solid state properties of cyclodextrin complexes of selected drug molecules UR - http://hdl.handle.net/11427/17902 ER - | en_ZA |
