Surfactant Protein-D is essential for immunity to Helminth Infection

 

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dc.contributor.author Thawer, Sumaiyya en_ZA
dc.contributor.author Auret, Jennifer en_ZA
dc.contributor.author Schnoeller, Corinna en_ZA
dc.contributor.author Chetty, Alisha en_ZA
dc.contributor.author Smith, Katherine en_ZA
dc.contributor.author Darby, Matthew en_ZA
dc.contributor.author Roberts, Luke en_ZA
dc.contributor.author Mackay, Rosie-Marie en_ZA
dc.contributor.author Whitwell, Harry J en_ZA
dc.contributor.author Timms, John F en_ZA
dc.contributor.author Madsen, Jens en_ZA
dc.contributor.author Selkirk, Murray E en_ZA
dc.contributor.author Brombacher, Frank en_ZA
dc.contributor.author Clark, Howard William en_ZA
dc.contributor.author Horsnell, William G C en_ZA
dc.date.accessioned 2016-03-08T10:54:20Z
dc.date.available 2016-03-08T10:54:20Z
dc.date.issued 2016 en_ZA
dc.identifier.citation Thawer, S., Auret, J., Schnoeller, C., Chetty, A., Smith, K., Darby, M., ... & Madsen, J. (2016). Surfactant Protein-D is essential for immunity to Helminth Infection. PLoS Pathog, 12(2), e1005461. doi:10.1371/journal.ppat.1005461 en_ZA
dc.identifier.uri http://dx.doi.org/10.1371/journal.ppat.1005461 en_ZA
dc.identifier.uri http://hdl.handle.net/11427/17572
dc.description.abstract Author Summary Infections by parasitic worms are very common, and controlling them is a major medical and veterinary challenge. Very few drugs exist to treat them, and the parasites can develop resistance to these. In order to find new ways to control worm infections, understanding how our immune system responds to them is essential. Many important parasitic worm infections move through the host lung. In this study we show that a major secreted protein in the lung, Surfactant Protein D (SP-D), is essential for immunity to a parasitic worm infection. We found that this protein binds to worm larvae in the lung to help the immune system kill them. Infecting mice that do not express SP-D with worms demonstrates SP-D is important in this immune response. These mice are unable to launch an effective anti-worm immune response and have many more worms in their intestine compared to mice that do express SP-D. We also show that if we increase SP-D levels in the lung the mouse has better immunity to worms. Together this shows for the first time that SP-D is very important for immunity to worm infections. en_ZA
dc.language.iso eng en_ZA
dc.publisher Public Library of Science en_ZA
dc.rights This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source PLoS One en_ZA
dc.source.uri http://journals.plos.org/plospathogens en_ZA
dc.subject.other Alveolar macrophages en_ZA
dc.subject.other Helminth infections en_ZA
dc.subject.other Host-pathogen interactions en_ZA
dc.subject.other Infectious disease immunology en_ZA
dc.subject.other Immunity en_ZA
dc.subject.other Cell-mediated immunity en_ZA
dc.subject.other Enzyme-linked immunoassays en_ZA
dc.subject.other Immune response en_ZA
dc.title Surfactant Protein-D is essential for immunity to Helminth Infection en_ZA
dc.type Journal Article en_ZA
dc.rights.holder © 2016 Thawer et al en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Institute of Infectious Disease and Molecular Medicine en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Thawer, S., Auret, J., Schnoeller, C., Chetty, A., Smith, K., Darby, M., ... Horsnell, W. G. C. (2016). Surfactant Protein-D is essential for immunity to Helminth Infection. <i>PLoS One</i>, http://hdl.handle.net/11427/17572 en_ZA
dc.identifier.chicagocitation Thawer, Sumaiyya, Jennifer Auret, Corinna Schnoeller, Alisha Chetty, Katherine Smith, Matthew Darby, Luke Roberts, et al "Surfactant Protein-D is essential for immunity to Helminth Infection." <i>PLoS One</i> (2016) http://hdl.handle.net/11427/17572 en_ZA
dc.identifier.vancouvercitation Thawer S, Auret J, Schnoeller C, Chetty A, Smith K, Darby M, et al. Surfactant Protein-D is essential for immunity to Helminth Infection. PLoS One. 2016; http://hdl.handle.net/11427/17572. en_ZA
dc.identifier.ris TY - Journal Article AU - Thawer, Sumaiyya AU - Auret, Jennifer AU - Schnoeller, Corinna AU - Chetty, Alisha AU - Smith, Katherine AU - Darby, Matthew AU - Roberts, Luke AU - Mackay, Rosie-Marie AU - Whitwell, Harry J AU - Timms, John F AU - Madsen, Jens AU - Selkirk, Murray E AU - Brombacher, Frank AU - Clark, Howard William AU - Horsnell, William G C AB - Author Summary Infections by parasitic worms are very common, and controlling them is a major medical and veterinary challenge. Very few drugs exist to treat them, and the parasites can develop resistance to these. In order to find new ways to control worm infections, understanding how our immune system responds to them is essential. Many important parasitic worm infections move through the host lung. In this study we show that a major secreted protein in the lung, Surfactant Protein D (SP-D), is essential for immunity to a parasitic worm infection. We found that this protein binds to worm larvae in the lung to help the immune system kill them. Infecting mice that do not express SP-D with worms demonstrates SP-D is important in this immune response. These mice are unable to launch an effective anti-worm immune response and have many more worms in their intestine compared to mice that do express SP-D. We also show that if we increase SP-D levels in the lung the mouse has better immunity to worms. Together this shows for the first time that SP-D is very important for immunity to worm infections. DA - 2016 DB - OpenUCT DO - 10.1371/journal.ppat.1005461 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - Surfactant Protein-D is essential for immunity to Helminth Infection TI - Surfactant Protein-D is essential for immunity to Helminth Infection UR - http://hdl.handle.net/11427/17572 ER - en_ZA


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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.