The enclathration of alcohols by cholic acid

 

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dc.contributor.advisor Nassimbeni, Luigi R en_ZA
dc.contributor.author Jones, Elizabeth Louise en_ZA
dc.date.accessioned 2016-02-22T07:20:41Z
dc.date.available 2016-02-22T07:20:41Z
dc.date.issued 1989 en_ZA
dc.identifier.citation Jones, E. 1989. The enclathration of alcohols by cholic acid. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/17185
dc.description Bibliography: pages 220-231. en_ZA
dc.description.abstract A series of crystalline Cholic acid inclusion compounds were studied with a view to understanding the role of guest molecules in inducing and stabilizing a particular Cholic acid (host) lattice structure. Alcohols in the series CH₃(CH₂nOH (n= 0 to 3 and 2-propanol) were employed as guest molecules and enclathrated in the host lattice of Cholic acid during crystallization. Single crystal structure analyses were performed by X-ray diffraction. Two types of molecular packing were identified. Cholic acid inclusion compounds with methanol, ethanol and 1-propanol are characterized by a 3-D host and guest molecule network stabilized by hydrogen bonds with symmetry of P2₁2₁2₁ space group. The guest molecules 2- propanol and 1-butanol, by nature of their size, induce a molecular packing with a larger guest cavity than that in the P2₁2₁2₁ space structures. Symmetrically defined by the P6₅22 space group, the crystal lattice is characterized by a helix of Cholic acid molecules generated by the six-fold screw axis through the origin and parallel to the c axis. The lattice is stabilized by an intricate hydrogen bonding scheme. The conformation of Cholic acid (particularly that of the flexible side-chain) in the two types of molecular packing was studied. The size and shape of the guest cavities created by the host lattices were examined. Thermal analyses (Thermogravimetric analysis and Differential Scanning Calorimetry) were performed on these compounds to examine the guest content and the strength of host-guest interactions. ₁₂₃₅ en_ZA
dc.language.iso eng en_ZA
dc.subject.other Chemistry en_ZA
dc.subject.other Cholic acid en_ZA
dc.subject.other Alcohols en_ZA
dc.title The enclathration of alcohols by cholic acid en_ZA
dc.type Master Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Science en_ZA
dc.publisher.department Department of Chemistry en_ZA
dc.type.qualificationlevel Masters
dc.type.qualificationname MSc en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Jones, E. L. (1989). <i>The enclathration of alcohols by cholic acid</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/17185 en_ZA
dc.identifier.chicagocitation Jones, Elizabeth Louise. <i>"The enclathration of alcohols by cholic acid."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 1989. http://hdl.handle.net/11427/17185 en_ZA
dc.identifier.vancouvercitation Jones EL. The enclathration of alcohols by cholic acid. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 1989 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/17185 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Jones, Elizabeth Louise AB - A series of crystalline Cholic acid inclusion compounds were studied with a view to understanding the role of guest molecules in inducing and stabilizing a particular Cholic acid (host) lattice structure. Alcohols in the series CH₃(CH₂nOH (n= 0 to 3 and 2-propanol) were employed as guest molecules and enclathrated in the host lattice of Cholic acid during crystallization. Single crystal structure analyses were performed by X-ray diffraction. Two types of molecular packing were identified. Cholic acid inclusion compounds with methanol, ethanol and 1-propanol are characterized by a 3-D host and guest molecule network stabilized by hydrogen bonds with symmetry of P2₁2₁2₁ space group. The guest molecules 2- propanol and 1-butanol, by nature of their size, induce a molecular packing with a larger guest cavity than that in the P2₁2₁2₁ space structures. Symmetrically defined by the P6₅22 space group, the crystal lattice is characterized by a helix of Cholic acid molecules generated by the six-fold screw axis through the origin and parallel to the c axis. The lattice is stabilized by an intricate hydrogen bonding scheme. The conformation of Cholic acid (particularly that of the flexible side-chain) in the two types of molecular packing was studied. The size and shape of the guest cavities created by the host lattices were examined. Thermal analyses (Thermogravimetric analysis and Differential Scanning Calorimetry) were performed on these compounds to examine the guest content and the strength of host-guest interactions. ₁₂₃₅ DA - 1989 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1989 T1 - The enclathration of alcohols by cholic acid TI - The enclathration of alcohols by cholic acid UR - http://hdl.handle.net/11427/17185 ER - en_ZA


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