Broadly neutralizing antibody responses in a large longitudinal sub-Saharan HIV primary infection cohort

 

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dc.contributor.author Landais, Elise en_ZA
dc.contributor.author Huang, Xiayu en_ZA
dc.contributor.author Havenar-Daughton, Colin en_ZA
dc.contributor.author Murrell, Ben en_ZA
dc.contributor.author Price, Matt A en_ZA
dc.contributor.author Wickramasinghe, Lalinda en_ZA
dc.contributor.author Ramos, Alejandra en_ZA
dc.contributor.author Bian, Charoan B en_ZA
dc.contributor.author Simek, Melissa en_ZA
dc.contributor.author Allen, Susan en_ZA
dc.contributor.author Karita, Etienne en_ZA
dc.contributor.author Kilembe, William en_ZA
dc.contributor.author Lakhi, Shabir en_ZA
dc.contributor.author Inambao, Mubiana en_ZA
dc.contributor.author Kamali, Anatoli en_ZA
dc.contributor.author Sanders, Eduard J en_ZA
dc.contributor.author Anzala, Omu en_ZA
dc.contributor.author Edward, Vinodh en_ZA
dc.contributor.author Bekker, Linda-Gail en_ZA
dc.contributor.author Tang, Jianming en_ZA
dc.contributor.author Gilmour, Jill en_ZA
dc.contributor.author Kosakovsky-Pond, Sergei L en_ZA
dc.contributor.author Phung, Pham en_ZA
dc.contributor.author Wrin, Terri en_ZA
dc.contributor.author Crotty, Shane en_ZA
dc.contributor.author Godzik, Adam en_ZA
dc.contributor.author Poignard, Pascal en_ZA
dc.date.accessioned 2016-02-10T14:45:27Z
dc.date.available 2016-02-10T14:45:27Z
dc.date.issued 2016 en_ZA
dc.identifier.citation Landais, E., Huang, X., Havenar-Daughton, C., Murrell, B., Price, M. A., Wickramasinghe, L., ... & Karita, E. (2016). Broadly neutralizing antibody responses in a large longitudinal sub-Saharan HIV primary infection cohort. PLoS pathogens, 12(1), e1005369. doi:10.1371/journal.ppat.1005369 en_ZA
dc.identifier.uri http://dx.doi.org/10.1371/journal.ppat.1005369 en_ZA
dc.identifier.uri http://hdl.handle.net/11427/16943
dc.description.abstract Author Summary Understanding how HIV-1-broadly neutralizing antibodies (bnAbs) develop during natural infection is essential to the design of an efficient HIV vaccine. We studied kinetics and correlates of neutralization breadth in a large sub-Saharan African longitudinal cohort of 439 participants with primary HIV-1 infection. Broadly nAb responses developed in 15% of individuals, on average three years after infection. Broad neutralization was associated with high viral load, low CD4+ T cell counts, virus subtype C infection and HLA*A3(-) genotype. A correlation with high overall plasma IgG levels and anti-Env binding titers was also found. Specificity mapping of the bnAb responses showed that glycan-dependent epitopes, in particular the N332 region, were most commonly targeted, in contrast to other bnAb epitopes, suggesting that the HIV Env N332-glycan epitope region may be a favorable target for vaccine design. en_ZA
dc.language.iso eng en_ZA
dc.publisher Public Library of Science en_ZA
dc.rights This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source PLoS One en_ZA
dc.source.uri http://journals.plos.org/plospathogens en_ZA
dc.subject.other HIV-1 en_ZA
dc.subject.other Viral load en_ZA
dc.subject.other Antibody response en_ZA
dc.subject.other Antibodies en_ZA
dc.subject.other HIV-2 en_ZA
dc.subject.other Adsorption en_ZA
dc.subject.other HIV en_ZA
dc.subject.other T helper cells en_ZA
dc.title Broadly neutralizing antibody responses in a large longitudinal sub-Saharan HIV primary infection cohort en_ZA
dc.type Journal Article en_ZA
dc.rights.holder © 2016 Landais et al en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Desmond Tutu HIV Centre en_ZA
uct.type.filetype Text
uct.type.filetype Image


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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.