High burden of human papillomavirus (HPV) infection among young women in KwaZulu-Natal, South Africa

 

Show simple item record

dc.contributor.author Ebrahim, Sumayyah en_ZA
dc.contributor.author Mndende, Xolani K en_ZA
dc.contributor.author Kharsany, Ayesha B M en_ZA
dc.contributor.author Mbulawa, Zizipho Z A en_ZA
dc.contributor.author Naranbhai, Vivek en_ZA
dc.contributor.author Frohlich, Janet en_ZA
dc.contributor.author Werner, Lise en_ZA
dc.contributor.author Samsunder, Natasha en_ZA
dc.contributor.author Karim, Quarraisha Abdool en_ZA
dc.contributor.author Williamson, Anna-Lise en_ZA
dc.date.accessioned 2016-02-10T14:44:57Z
dc.date.available 2016-02-10T14:44:57Z
dc.date.issued 2016 en_ZA
dc.identifier.citation Ebrahim, S., Mndende, X. K., Kharsany, A. B., Mbulawa, Z. Z., Naranbhai, V., Frohlich, J., ... & Williamson, A. L. (2016). High burden of human papillomavirus (HPV) infection among young women in KwaZulu-Natal, South Africa. PloS one, 11(1). doi:10.1371/journal.pone.0146603 en_ZA
dc.identifier.uri http://dx.doi.org/10.1371/journal.pone.0146603 en_ZA
dc.identifier.uri http://hdl.handle.net/11427/16941
dc.description.abstract Objectives HPV infection causes cervical cancer, yet information on prevalence and risk factors for HPV in Africa remain sparse. This study describes the prevalence of HPV genotypes and risk factors associated with HPV among young women ≤ 30 years of age in KwaZulu-Natal (KZN), South Africa. METHODS: Cervicovaginal lavage samples were tested for HPV genotypes in 224 women enrolled in a prospective cohort study. Clinical, behavioural and demographic data were collected. We measured prevalence of HPV genotypes and using logistic regression, examined for factors associated with HPV. RESULTS: Median age of participants was 21 years [interquartile range (IQR):18-23]. The overall prevalence of HPV was 76.3% (171/224) with multiple and single genotypes prevalent in 56.3% and 20.1% of women respectively. Proportion of women with high-risk genotypes (16, 18, 31, 33, 35, 39, 45, 51, 52, 56 and 58) was 54.5%. Women not living with their partner [adjusted odds ratio (aOR)] = 3.42 95% CI1.22-9.60; p = 0.019), was significantly associated with HPV infection and high-risk HPV genotype infection. CONCLUSION: The high burden of HPV and associated risk behaviours highlight the need to intensify behavioural interventions to prevent HPV acquisition in young women. The large scale delivery of HPV vaccine should be prioritised to prevent HPV acquisition and reduce HPV-related morbidity. en_ZA
dc.language.iso eng en_ZA
dc.publisher Public Library of Science en_ZA
dc.rights This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source PLoS One en_ZA
dc.source.uri http://journals.plos.org/plosone en_ZA
dc.subject.other Human papillomavirus infection en_ZA
dc.subject.other Vaccines en_ZA
dc.subject.other Human papillomavirus en_ZA
dc.subject.other Sexually transmitted diseases en_ZA
dc.subject.other Cervical cancer en_ZA
dc.subject.other Copulation en_ZA
dc.subject.other Human sexual behavior en_ZA
dc.subject.other South Africa en_ZA
dc.title High burden of human papillomavirus (HPV) infection among young women in KwaZulu-Natal, South Africa en_ZA
dc.type Journal Article en_ZA
dc.rights.holder © 2016 Ebrahim et al en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Virology en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Ebrahim, S., Mndende, X. K., Kharsany, A. B. M., Mbulawa, Z. Z. A., Naranbhai, V., Frohlich, J., ... Williamson, A. (2016). High burden of human papillomavirus (HPV) infection among young women in KwaZulu-Natal, South Africa. <i>PLoS One</i>, http://hdl.handle.net/11427/16941 en_ZA
dc.identifier.chicagocitation Ebrahim, Sumayyah, Xolani K Mndende, Ayesha B M Kharsany, Zizipho Z A Mbulawa, Vivek Naranbhai, Janet Frohlich, Lise Werner, Natasha Samsunder, Quarraisha Abdool Karim, and Anna-Lise Williamson "High burden of human papillomavirus (HPV) infection among young women in KwaZulu-Natal, South Africa." <i>PLoS One</i> (2016) http://hdl.handle.net/11427/16941 en_ZA
dc.identifier.vancouvercitation Ebrahim S, Mndende XK, Kharsany ABM, Mbulawa ZZA, Naranbhai V, Frohlich J, et al. High burden of human papillomavirus (HPV) infection among young women in KwaZulu-Natal, South Africa. PLoS One. 2016; http://hdl.handle.net/11427/16941. en_ZA
dc.identifier.ris TY - Journal Article AU - Ebrahim, Sumayyah AU - Mndende, Xolani K AU - Kharsany, Ayesha B M AU - Mbulawa, Zizipho Z A AU - Naranbhai, Vivek AU - Frohlich, Janet AU - Werner, Lise AU - Samsunder, Natasha AU - Karim, Quarraisha Abdool AU - Williamson, Anna-Lise AB - Objectives HPV infection causes cervical cancer, yet information on prevalence and risk factors for HPV in Africa remain sparse. This study describes the prevalence of HPV genotypes and risk factors associated with HPV among young women ≤ 30 years of age in KwaZulu-Natal (KZN), South Africa. METHODS: Cervicovaginal lavage samples were tested for HPV genotypes in 224 women enrolled in a prospective cohort study. Clinical, behavioural and demographic data were collected. We measured prevalence of HPV genotypes and using logistic regression, examined for factors associated with HPV. RESULTS: Median age of participants was 21 years [interquartile range (IQR):18-23]. The overall prevalence of HPV was 76.3% (171/224) with multiple and single genotypes prevalent in 56.3% and 20.1% of women respectively. Proportion of women with high-risk genotypes (16, 18, 31, 33, 35, 39, 45, 51, 52, 56 and 58) was 54.5%. Women not living with their partner [adjusted odds ratio (aOR)] = 3.42 95% CI1.22-9.60; p = 0.019), was significantly associated with HPV infection and high-risk HPV genotype infection. CONCLUSION: The high burden of HPV and associated risk behaviours highlight the need to intensify behavioural interventions to prevent HPV acquisition in young women. The large scale delivery of HPV vaccine should be prioritised to prevent HPV acquisition and reduce HPV-related morbidity. DA - 2016 DB - OpenUCT DO - 10.1371/journal.pone.0146603 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - High burden of human papillomavirus (HPV) infection among young women in KwaZulu-Natal, South Africa TI - High burden of human papillomavirus (HPV) infection among young women in KwaZulu-Natal, South Africa UR - http://hdl.handle.net/11427/16941 ER - en_ZA


Files in this item

This item appears in the following Collection(s)

Show simple item record

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.