The role of IL-4 and Th2-like cytokines in pulmonary tuberculosis
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University of Cape Town
Tuberculosis (TB) vaccine candidates have been mostly ineffective and it remains unclear as to what constitutes protective host immunity. Despite high levels of IFN-γ at the site of disease, the Th1 cytokine associated with protection, many individuals still have progressive active TB. Whether a Th2-like immune response (IL-4; IL-4δ2; IL-9) can subvert protective host immunity requires clarification.
Includes bibliographical references
Pooran, A. 2015. The role of IL-4 and Th2-like cytokines in pulmonary tuberculosis. University of Cape Town.