Assessment at antiretroviral clinics during TB treatment reduces loss to follow-up among HIV-infected patients

 

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dc.contributor.author Pepper, Dominique J en_ZA
dc.contributor.author Marais, Suzaan en_ZA
dc.contributor.author Bhaijee, Feriyl en_ZA
dc.contributor.author Wilkinson, Robert J en_ZA
dc.contributor.author De Azevedo, Virginia en_ZA
dc.contributor.author Meintjes, Graeme en_ZA
dc.date.accessioned 2016-01-11T06:56:15Z
dc.date.available 2016-01-11T06:56:15Z
dc.date.issued 2012 en_ZA
dc.identifier.citation Pepper, D. J., Marais, S., Bhaijee, F., Wilkinson, R. J., De Azevedo, V., & Meintjes, G. (2012). Assessment at antiretroviral clinics during TB treatment reduces loss to follow-up among HIV-infected patients. PloS one, 7(6), e37634. doi:10.1371/journal.pone.0037634 en_ZA
dc.identifier.uri http://hdl.handle.net/11427/16312
dc.identifier.uri http://dx.doi.org/10.1371/journal.pone.0037634
dc.description.abstract Setting: A South African township clinic where loss to follow-up during TB treatment may prevent HIV-infected TB patients from receiving life-saving ART. Objective: To determine factors associated with loss to follow-up during TB treatment. Design: Regression analyses of a cohort of ART-eligible TB patients who commenced TB treatment and were followed for 24 weeks. RESULTS: Of 111 ART-eligible TB patients, 15 (14%) died in the ensuing 24 weeks. Of the remaining 96 TB patients, 11 (11%) were lost to follow-up. All TB patients lost to follow-up did not initiate ART. Of 85 TB patients in follow-up, 62 (73%) initiated ART 56 days after TB diagnosis (median, IQR 33-77 days) and 31 days after initial assessment at an ART clinic (median, IQR: 18-55 days). The median duration from TB diagnosis to initial assessment at an ART clinic was 19 days (IQR: 7-48 days). At 24 weeks, 6 of 85 (7%) TB patients who presented to an ART clinic for assessment were lost to follow-up, compared to 5 of 11 (45%) TB patients who did not present to an ART clinic for assessment. Logistic regression analysis (adjusted odds ratio  = 0.1, 95% confidence interval [95% CI]: 0.03-0.66) and our Cox proportional hazards model (hazard ratio  = 0.2, 95% CI: 0.04-0.68) confirmed that assessment at an ART clinic during TB treatment reduced loss to follow-up. CONCLUSION: Assessment at antiretroviral clinics for HIV care by trained health-care providers reduces loss to follow-up among HIV-infected patients with TB. en_ZA
dc.language.iso eng en_ZA
dc.publisher Public Library of Science en_ZA
dc.rights credited. en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source PLoS One en_ZA
dc.source.uri http://journals.plos.org/plosone en_ZA
dc.subject.other Tuberculosis en_ZA
dc.subject.other Antiretroviral therapy en_ZA
dc.subject.other Tuberculosis diagnosis and management en_ZA
dc.subject.other HIV en_ZA
dc.subject.other Adults en_ZA
dc.subject.other Antiretrovirals en_ZA
dc.subject.other History of tuberculosis en_ZA
dc.subject.other Drug screening en_ZA
dc.title Assessment at antiretroviral clinics during TB treatment reduces loss to follow-up among HIV-infected patients en_ZA
dc.type Journal Article en_ZA
dc.rights.holder © 2012 Pepper et al en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Medicine en_ZA
uct.type.filetype Text
uct.type.filetype Image


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