Polymorphisms in the non-muscle myosin heavy chain gene (MYH9) are associated with lower glomerular filtration rate in mixed ancestry diabetic subjects from South Africa

 

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dc.contributor.author Matsha, Tandi Edith en_ZA
dc.contributor.author Masconi, Katya en_ZA
dc.contributor.author Yako, Yandiswa Yolanda en_ZA
dc.contributor.author Hassan, Mogamat Shafick en_ZA
dc.contributor.author Macharia, Muiriri en_ZA
dc.contributor.author Erasmus, Rajiv Timothy en_ZA
dc.contributor.author Kengne, Andre Pascal en_ZA
dc.date.accessioned 2016-01-11T06:56:15Z
dc.date.available 2016-01-11T06:56:15Z
dc.date.issued 2012 en_ZA
dc.identifier.citation Matsha, T. E., Masconi, K., Yako, Y. Y., Hassan, M. S., Macharia, M., Erasmus, R. T., & Kengne, A. P. (2012). Polymorphisms in the non-muscle myosin heavy chain gene (MYH9) are associated with lower glomerular filtration rate in mixed ancestry diabetic subjects from South Africa. PLoS ONE, 7(12). doi:10.1371/journal.pone.0052529 en_ZA
dc.identifier.uri http://hdl.handle.net/11427/16311
dc.identifier.uri http://dx.doi.org/10.1371/journal.pone.0052529
dc.description.abstract Objective: Though single nucleotide polymorphisms (SNPs) in the non-muscle myosin gene (MYH9) have been reported to explain most of the excess risk of nondiabetic chronic kidney disease (CKD), in African-Americans, some studies have also shown associations with diabetic end-stage renal disease. We investigated the association of MYH9 SNPs with renal traits in a mixed-ancestry South African population prone to diabetes. Research Design and METHODS: Three SNPs known to be associated with CKD (rs4821480, rs5756152 and rs12107) were genotyped using Taqman assay in 716 adults (198 with diabetes) from the Bellville-South community, Cape Town. Glomerular filtration rate was estimated (eGFR) and urinary albumin/creatinine ratio (ACR) assessed. Multivariable regressions were used to relate the SNPs with renal traits. RESULTS: Mean age was 53.6 years, with the expected differences observed in characteristics by diabetic status. Significant associations were found between rs575152 and serum creatinine, and eGFR in the total population, and in diabetic participants (all p≤0.003), but not in non-diabetics (all p≥0.16), with significant interactions by diabetes status (interaction-p≤0.009). The association with ACR was borderline in diabetic participants (p = 0.05) and non-significant in non-diabetics (p = 0.85), with significant interaction (interaction p = 0.02). rs12107 was associated with fasting-, 2-hour glucose and HbA1c in diabetic participants only (interaction-p≤0.003), but not with renal traits. CONCLUSION: MYH9 SNPs were associated with renal traits only in diabetic participants in this population. Our findings and other studies suggest that MYH9 may have a broader genetic risk effect on kidney diseases. en_ZA
dc.language.iso eng en_ZA
dc.publisher Public Library of Science en_ZA
dc.rights This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source PLoS One en_ZA
dc.source.uri http://journals.plos.org/plosone en_ZA
dc.subject.other Diabetes mellitus en_ZA
dc.subject.other Chronic kidney disease en_ZA
dc.subject.other Type 2 diabetes en_ZA
dc.subject.other Creatinine en_ZA
dc.subject.other Albumins en_ZA
dc.subject.other Kidneys en_ZA
dc.subject.other Blood pressure en_ZA
dc.subject.other Renal diseases en_ZA
dc.title Polymorphisms in the non-muscle myosin heavy chain gene (MYH9) are associated with lower glomerular filtration rate in mixed ancestry diabetic subjects from South Africa en_ZA
dc.type Journal Article en_ZA
dc.rights.holder © 2012 Matsha et al en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Medicine en_ZA
uct.type.filetype Text
uct.type.filetype Image


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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.